Validation of recall of body weight over a 26-year period in cohort members of the Adventist Health Study 2.

Purpose: The validity of recall of past body weight has been measured and tends to be high; however, the paucity of validation data for recall in older age is noteworthy given the need for accounting for age and disease-related weight change in prospective studies.

Methods: The Adventist Health Study-2 (AHS-2) is a prospective, questionnaire-based study (n = 96,710) that enrolled a cohort from 2002 through 2007 to investigate the role of lifestyle exposures (diet, physical activity, anthropometrics) and health on outcomes such as cancer and mortality.

Results: The mean difference between current weight reported 26 years earlier in AHS-1 and recall of past body weight in AHS-2 was only 0.

Effect of weight loss in adults on estimation of risk due to adiposity in a cohort study.

The effect of overweight and obesity on the risk of fatal disease tends to attenuate with age. To evaluate whether this effect is partly attributable to disease-related weight loss, we examined the prebaseline history of weight loss and diseases associated with weight loss among adults enrolled in a cohort study. We conducted an analysis of 7,855 adult cohort members of the Adventist Health Study (AHS) I who had provided anthropometric data on surveys at baseline and 17 years prior to baseline.

Factors associated with hepatic fibrosis in patients with chronic hepatitis C: a retrospective study of a large cohort of U.S. patients.

Goals: To determine the risk factors for stage 3 and 4 fibrosis in a large cohort of U.S. patients with chronic hepatitis C (CHC).

Octreotide/Midodrine therapy significantly improves renal function and 30-day survival in patients with type 1 hepatorenal syndrome.

Type 1 hepatorenal syndrome (HRS) can be a rapidly fatal consequence of liver failure. Recent studies have utilized vasoconstrictor therapies to combat splanchnic vasodilatation. We aimed to evaluate the efficacy of a promising treatment for type 1 HRS.

Clinical presentation of chronic hepatitis C in patients with end-stage renal disease and on hemodialysis versus those with normal renal function.

Background: The natural history of chronic hepatitis C (CHC) remains to be defined in patients with end-stage renal disease (ESRD).

Aims: To determine the clinical presentation of CHC and the factors associated with stage III-IV fibrosis in patients with CHC and ESRD.

Methods: The study included patients with CHC and ESRD (n = 91) or normal renal function (NRF, n = 159).

MELD score is a better prognostic model than Child-Turcotte-Pugh score or Discriminant Function score in patients with alcoholic hepatitis.

Background/aims: The aim of the present study was to compare MELD score, Child-Turcotte-Pugh (CTP) score, modified Maddrey's Discriminant Function (DF) score, and the related variables in predicting in-hospital mortality of patients with alcoholic hepatitis.

Methods: A retrospective chart review and statistical analyses were done on 202 patients consecutively admitted for alcoholic hepatitis from 1997 to 2002 at the Liver Unit at Rancho Los Amigos Medical Center.

Results: Twenty-nine patients died during the hospitalization.

Clinical significance of elevated alpha-fetoprotein (AFP) in patients with chronic hepatitis C, but not hepatocellular carcinoma.

Background: Although elevated serum alpha-fetoprotein (AFP) is often seen in patients with chronic hepatitis C (CHC), its prevalence, risk factors, and clinical significance remain to be determined.

Aims: The present study assessed the frequency of, the risk factors for, and the clinical significance of elevated AFP in patients with CHC, but not hepatocellular carcinoma.

Methods: This retrospective study utilized systematic chart review and statistical analyses to investigate 357 U.

Overweight and obesity, hepatic steatosis, and progression of chronic hepatitis C: a retrospective study on a large cohort of patients in the United States.

Background: Hepatic steatosis has been associated with chronic hepatitis C (CHC), but its prevalence, risk factors, and clinical significance remain to be determined.

Aims: The present study determined the frequency of, and risk factors for hepatic steatosis and its association with activity and progression of CHC in a large cohort of U.S.