Pharmacological evaluation of HM41322, a novel SGLT1/2 dual inhibitor, and .

HM41322 is a novel oral sodium-glucose cotransporter (SGLT) 1/2 dual inhibitor. In this study, the and pharmacokinetic and pharmacologic profiles of HM41322 were compared to those of dapagliflozin. HM41322 showed a 10-fold selectivity for SGLT2 over SGLT1.

Rhodium nanoparticles entrapped in boehmite nanofibers: recyclable catalyst for arene hydrogenation under mild conditions.

A new recyclable rhodium catalyst was synthesized by a simple procedure from readily available reagents, which showed high activities in the hydrogenation of various arenes under 1 atm H2 at room temperature.

Air-stable racemization catalyst for dynamic kinetic resolution of secondary alcohols at room temperature.

[reaction: see text] A novel racemization catalyst was synthesized for the dynamic kinetic resolution (DKR) of alcohols with a lipase at room temperature in the air. Furthermore, a polymer-supported derivative was also synthesized and tested as a recyclable catalyst for the aerobic DKR of alcohols.

Palladium nanoparticles entrapped in aluminum hydroxide: dual catalyst for alkene hydrogenation and aerobic alcohol oxidation.

[reaction: see text] A new aluminum hydroxide-supported palladium catalyst (1) made by a one-pot synthesis through nanoparticle generation and gelation shows a dual catalytic activity for olefinic hydrogenation and aerobic alcohol oxidation.