When and how to transplant in myelofibrosis - recent trends.

Allogeneic hematopoietic stem cell transplantation (AHSCT) is currently the only treatment modality that is capable of curing myelofibrosis (MF). Although outcomes of AHSCT have improved vastly in recent years owing to advancements in HLA typing, conditioning regimens, and supportive care, it remains a procedure with a considerable risk in MF patients due to conditioning regimen related toxicity, higher rates of graft failure, infections, and graft versus host disease (GVHD). Recent progress in the treatment and prevention of GVHD with post-transplant cyclophosphamide has also rendered transplantation from alternative donors feasible and safer, thus improving access to patients without HLA-identical donors.

NPM 1 Mutations in AML-The Landscape in 2023.

Acute myeloid leukemia (AML) represents 80% of acute leukemia in adults and is characterized by clonal expansion of hematopoietic stem cells secondary to genomic mutations, rendering a selective growth advantage to the mutant clones. NPM1 is found in around 30% of AML and clinically presents with leukocytosis, high blast percentage and extramedullary involvement. Considered as a "gate-keeper" mutation, NPM1 appears to be a "first hit" in the process of leukemogenesis and development of overt leukemia.

Quality of content reporting on two major oncology media websites: OncLive and Targeted Oncology.

Introduction: Oncology media websites such as Oncology Live (OncLive) and Targeted Oncology (TargetedOnc) play an important role in the dissemination of oncology news to patients and clinicians; however, the quality of the content on these websites has not been assessed. Our study aimed to analyze content from these websites and assess financial conflicts of interest (FCOI) amongst speakers interviewed on these websites.

Methods: Articles published on OncLive and TargetedOnc during October 2021, were prospectively captured and analyzed.

Tele-ophthalmology: Need of the hour.

Telemedicine and tele-ophthalmology have been in existence since many years, but have recently gained more importance in the present scenario of pandemic COVID-19. The attitude and perception of the doctors and patients has been changing gradually. Telemedicine has many advantages including providing care in inaccesible areas.

Stem cell homing: From physiology to therapeutics.

Stem cell homing is a multistep endogenous physiologic process that is also used by exogenously administered hematopoietic stem and progenitor cells (HSPCs). This multistep process involves cell migration and is essential for hematopoietic stem cell transplantation. The process can be manipulated to enhance ultimate engraftment potential, and understanding stem cell homing is also important to the understanding of stem cell mobilization.

Cardiac ALL: Most Unusual Occurrence of Lenalidomide-associated Acute Lymphoblastic Leukemia with Subsequent Cardiac Involvement.

Leukemic infiltration of the myocardium is an extremely rare complication and requires high clinical suspicion, as <5% pf patients are symptomatic. Commonly encountered cardiovascular complications are secondary to anemia, infections, and chemotherapy. We present an unusual case of biopsy-proven myocardial B-cell acute lymphoblastic leukemia (ALL) in an elderly male on chronic maintenance therapy with lenalidomide, with a previous history of multiple myeloma (MM) and subsequent ALL.

Emerging investigator series: oxidative potential of diesel exhaust particles: role of fuel, engine load, and emissions control.

Exposure to diesel exhaust particles (DEP) has been linked to adverse human health outcomes. DEPs are reactive and can directly or indirectly lead to oxidative stress, which promotes inflammation in the body. The oxidative potential (OP) of DEPs is not well understood, particularly for combustion with alternative fuels, under different engine loads, and in combination with modern emissions control devices.

A novel luciferase-based assay for the detection of Chimeric Antigen Receptors.

Chimeric Antigen Receptor-T (CAR-T) cell immunotherapy has produced dramatic responses in hematologic malignancies. One of the challenges in the field is the lack of a simple assay for the detection of CARs on the surface of immune effector cells. In this study, we describe a novel luciferase-based assay, termed Topanga Assay, for the detection of CAR expression.

Emerging biorefinery technologies for Indian forest industry to reduce GHG emissions.

The production of biofuels as alternative energy source over fossil fuels has gained immense interest over the years as it can contribute significantly to reduce the greenhouse gas (GHG) emissions from energy production and utilization. Also with rapidly increasing fuel price and fall in oil wells, the present scenario forces us to look for an alternative source of energy that will help us in the operation of industrial as well as the transportation sector. The pulp mills in India are one of the many options.