Publications by authors named "Nam-Mi Park"
Article Synopsis
- Diabetic cardiomyopathy (DCM) significantly contributes to health issues in diabetes patients, and the role of tetrahydrobiopterin (BH4) in this context has not been fully understood.
- Research in a rodent model revealed that BH4 deficiency leads to detrimental cardiac and mitochondrial changes, while supplementation with BH4 improved heart function and mitochondrial activity.
- The study identified BH4's interaction with a specific protein (CaMKK2) that activates crucial signaling pathways, offering insights into potential therapies for DCM via BH4 enhancement.
Background: The recanalization rate after coil embolization of unruptured aneurysms was compared between young and old age groups.
Methods: From May 2003 to December 2010, 636 patients with 715 saccular unruptured intracranial aneurysms (UIA) underwent endovascular coiling and were followed for at least 6 months. For comparative analysis, patients were categorized into two groups according to age 40: 42 patients with 46 aneurysms who were 40 years or younger (young age group) and 594 patients with 669 aneurysms who were older than 40 years (old age group).
Standard vs Modified Antiplatelet Preparation for Preventing Thromboembolic Events in Patients With High On-Treatment Platelet Reactivity Undergoing Coil Embolization for an Unruptured Intracranial Aneurysm: A Randomized Clinical Trial.
JAMA Neurol
July 2015
Importance: Thromboembolism is the most common complication in coiling for an unruptured aneurysm and is frequent in patients with high on-treatment platelet reactivity (HTPR) who are prescribed a standard antiplatelet preparation for its prevention.
Objective: To evaluate the effect of a modified antiplatelet preparation compared with a standard preparation in patients with HTPR undergoing coiling.
Design, Setting, And Participants: A prospective randomized open-label active-control trial with blinded outcome assessment at the Seoul National University Bundang Hospital from May 27, 2013, to April 7, 2014.
Purpose: To evaluate characteristics of delayed ischemic stroke after stent-assisted coil placement in cerebral aneurysms and to determine the optimal duration of dual antiplatelet therapy for its prevention.
Materials And Methods: This retrospective study was approved by the institutional review board, and the requirement to obtain written informed consent was waived. Of 1579 patients with 1661 aneurysms, 395 patients (25.
Introduction: The novel Low-profile Visualized Intraluminal Support (LVIS™, LVIS and LVIS Jr.) device was recently introduced for stent-supported coil embolization of intracranial aneurysms. Periprocedural and midterm follow-up results for its use in stent-supported coil embolization of unruptured aneurysms are presented herein.
View Article and Find Full Text PDFIntroduction: We evaluated the outcomes of middle cerebral artery bifurcation (MCAB) aneurysms treated with simple coiling using single or multiple catheters without stents or balloons.
Methods: This study included 100 patients with 103 MCAB aneurysms who underwent a simple coiling procedure without the adjuvant use of stents or balloons. The angiographic clinical outcomes and recurrence of these aneurysms were evaluated.