Mitogen-Activated Protein Kinase Kinase OsMEK2 Positively Regulates Ca Influx and Ferroptotic Cell Death during Rice Immune Responses.

Mitogen-activated protein (MAP) kinase (MAPK) signaling pathway is important in plant immune responses, involved in iron- and reactive oxygen species (ROS)-dependent ferroptotic cell death mediated by Ca. High Ca influx triggered iron-dependent ROS accumulation, lipid peroxidation, and subsequent hypersensitive response (HR) cell death in rice (). Apoplastic Ca chelation by EGTA during avirulent infection altered Ca, ROS, and Fe accumulation, increasing rice susceptibility to infection.

Cytoplasmic Ca influx mediates iron- and reactive oxygen species-dependent ferroptotic cell death in rice immunity.

Iron- and reactive oxygen species (ROS)-dependent ferroptosis occurs in plant cells. Ca acts as a conserved key mediator to control plant immune responses. Here, we report a novel role of cytoplasmic Ca influx regulating ferroptotic cell death in rice immunity using pharmacological approaches.

Rice iron storage protein ferritin 2 (OsFER2) positively regulates ferroptotic cell death and defense responses against .

Ferritin is a ubiquitous iron storage protein that regulates iron homeostasis and oxidative stress in plants. Iron plays an important role in ferroptotic cell death response of rice () to infection. Here, we report that rice ferritin 2, OsFER2, is required for iron- and reactive oxygen species (ROS)-dependent ferroptotic cell death and defense response against the avirulent INA168.

The NIN-Like Protein OsNLP2 Negatively Regulates Ferroptotic Cell Death and Immune Responses to in Rice.

Nodule inception (NIN)-like proteins (NLPs) have a central role in nitrate signaling to mediate plant growth and development. Here, we report that OsNLP2 negatively regulates ferroptotic cell death and immune responses in rice during infection. OsNLP2 was localized to the plant cell nucleus, suggesting that it acts as a transcription factor.

Mitogen-Activated Protein Kinase OsMEK2 and OsMPK1 Signaling Is Required for Ferroptotic Cell Death in Rice- Interactions.

Mitogen-activated protein kinase (MAPK) signaling is required for plant cell death responses to invading microbial pathogens. Iron- and reactive oxygen species (ROS)-dependent ferroptotic cell death occurs in rice () during an incompatible rice- interaction. Here, we show that rice MAP kinase (OsMEK2 and OsMPK1) signaling cascades are involved in iron- and ROS-dependent ferroptotic cell death responses of rice to infection using knock-out mutant and and overexpression rice plants.