Publications by authors named "Nam K Ku"
Article Synopsis
- Microscopic examination of tissue is crucial in pathology, but traditional histology methods are time-consuming, destructive, and not well-suited for modern precision medicine, causing delays in diagnosis.
- AI-based techniques, like those developed by PictorLabs, have shown potential to streamline this process by generating quick diagnostic images using machine learning.
- In a study involving lymph node biopsies, virtual H&E stains performed comparably to traditional chemical stains, achieving higher stain quality and similar diagnostic accuracy, indicating that virtual stains may be a viable alternative for clinical assessments.
Article Synopsis
- Patients with core-binding factor (CBF) acute myeloid leukemia (AML) show better remission rates and longer survival compared to other AML subtypes, but around 40% still experience relapse.
- A study of 537 CBF-AML patients revealed important differences in cytogenetic abnormalities between those with two specific genetic mutations: patients with inv(16) had more trisomies while those with t(8;21) had higher rates of certain deletions.
- Multivariable analyses indicated that specific chromosomal abnormalities could impact survival outcomes differently for these two mutations, with trisomy 8 benefiting patients with inv(16) and hypodiploidy improving outcomes for those with t(8;21).
http://journals.sagepub.com/doi/10.
View Article and Find Full Text PDFBackground: Although the prognosis of core-binding factor (CBF) acute myeloid leukemia (AML) is better than other subtypes of AML, 30% of patients still relapse and may require allogeneic hematopoietic cell transplantation (alloHCT). However, there is no validated widely accepted scoring system to predict patient subsets with higher risk of relapse.
Methods: Eleven centers in the US and Europe evaluated 247 patients with t(8;21)(q22;q22).
Use of CD42b immunohistochemical stain for the detection of Histoplasma.
Ann Diagn Pathol
February 2018
In pathologic specimen, Histoplasma capsulatum can frequently be identified by morphology and special stains such as GMS and PAS. Incidentally, we noted unusual staining of the platelet associated marker CD42b/GP1b expressed on the surface of fungal organisms. Evaluation of additional cases demonstrated that a majority of histoplasmosis cases (15/18 cases; 83%) showed positive staining with CD42b/GP1b, comparable to GMS stain results.
View Article and Find Full Text PDFprotein is a serine/threonine kinase with 766 amino acids. Approximately 15% of human cancers harbor mutations as well as other anomalies (amplifications, fusions). Somatic mutations mainly occur in the catalytic kinase domain (CR3), and the predominant mutation is p.
View Article and Find Full Text PDF