Rational Design of Biocompatible Ir(III) Photosensitizer to Overcome Drug-Resistant Cancer via Oxidative Autophagy Inhibition.

Autophagy is a crucial quality control mechanism that degrades damaged cellular components through lysosomal fusion with autophagosomes. However, elevated autophagy levels can promote drug resistance in cancer cells, enhancing their survival. Downregulation of autophagy through oxidative stress is a clinically promising strategy to counteract drug resistance, yet precise control of oxidative stress in autophagic proteins remains challenging.

Hydrogen sulfide: A whiff of trouble for cancer cell survival.

Hydrogen sulfide (HS) can regulate biological processes by post-translational persulfidation of proteins at select cysteine residues. In this issue of Molecular Cell, Zheng et al. identify the enzyme SAHH as an HS substrate, which upon persulfidation disrupts homocysteine metabolism and sensitizes lung cancer cells to ferroptosis.

Consecutive assessment of recovery after peripheral nerve injury of the sciatic nerve within the same rat using PET/MRI.

Background: Positron emission tomography (PET) has been reported as effective in diagnosing peripheral nerve injury (PNI). However, there is a lack of studies evaluating different degrees of PNI using PET within the same individual to reduce errors due to interindividual differences.

Purpose: To evaluate the recovery process in the same rat after sciatic nerve injury using PET/magnetic resonance imaging (MRI).

Evaluation of peripheral nerve injury according to the severity of damage using F-FDG PET/MRI in a rat Model of sciatic nerve injury.

Objectives: We ascertained that the PET scan may be a valuable imaging modality for the noninvasive, objective diagnosis of neuropathic pain caused by peripheral nerve injury through the previous study. This study aimed to assess peripheral nerve damage according to severity usingF-FDG PET/MRI of the rat sciatic nerve.

Methods: Eighteen rats were divided into three groups: 30-second (G1), 2-minute (G2), and 5-minute (G3) crushing injuries.

Impact of cardiac rehabilitation on cardiovascular event in Korea.

This study aimed to evaluate the effects of cardiac rehabilitation (CR) on major adverse cardiac events (MACE) among patients who underwent PCI procedure. We used data from the electronic medical records (EMR) of a tertiary hospital in Seoul, Korea, from January 2014 to February 2020. Data from 2988 patients who had experienced their first acute coronary syndrome (ACS) and had undergone percutaneous coronary intervention (PCI) were included during the study period.

Evaluation of the Photoplethysmogram-Based Deep Learning Model for Continuous Respiratory Rate Estimation in Surgical Intensive Care Unit.

The respiratory rate (RR) is a significant indicator to evaluate a patient's prognosis and status; however, it requires specific instrumentation or estimates from other monitored signals. A photoplethysmogram (PPG) is extensively used in clinical environments as well as in intensive care units (ICUs) to primarily monitor peripheral circulation while capturing indirect information about intrathoracic pressure changes. This study aims to apply and evaluate several deep learning models using a PPG for the continuous and accurate estimation of the RRs of patients.

Identification of predictive factors for early relapse in patients with unresectable stage III non-small cell lung cancer receiving consolidation durvalumab after concurrent chemoradiation therapy.

Background: Patients with locally advanced, unresectable, non-small cell lung cancer (NSCLC) receiving definitive concurrent chemoradiation therapy (CCRT) benefit from durvalumab consolidation therapy. However, predictive factors for early relapse during durvalumab maintenance have not yet been identified.

Methods: The present study included the lung cancer cohort of the Catholic Medical Centers at the Catholic University of Korea from January 2018 to December 2021.

V-Mail: 3D-Enabled Correspondence About Spatial Data on (Almost) All Your Devices.

We present V-Mail, a framework of cross-platform applications, interactive techniques, and communication protocols for improved multi-person correspondence about spatial 3D datasets. Inspired by the daily use of e-mail, V-Mail seeks to enable a similar style of rapid, multi-person communication accessible on any device; however, it aims to do this in the new context of spatial 3D communication, where limited access to 3D graphics hardware typically prevents such communication. The approach integrates visual data storytelling with data exploration, spatial annotations, and animated transitions.

Multifunctional-high resolution imaging plate based on hydrophilic graphene for digital pathology.

In the present study, we showed that hydrophilic graphene can serve as an ideal imaging plate for biological specimens. Graphene being a single-atom-thick semi-metal with low secondary electron emission, array tomography analysis of serial sections of biological specimens on a graphene substrate showed excellent image quality with improved-axis resolution, without including any conductive surface coatings. However, the hydrophobic nature of graphene makes the placement of biological specimens difficult; graphene functionalized with polydimethylsiloxane oligomer was fabricated using a simple soft lithography technique and then processed with oxygen plasma to provide hydrophilic graphene with minimal damage to graphene.

Dual-Modulated Release of a Cytotoxic Photosensitizer Using Photogenerated Reactive Oxygen Species and Glutathione.

Reversible thiol-disulfide exchange chemistry is of particular interest in drug delivery systems. However, high levels of glutathione (GSH) in cancer cells are hard to distinguish from GSH in normal cells, resulting in unmanageable cytotoxic drug release. This study investigates the spatiotemporally-controlled irreversible degradation of Ir-based photosensitizer (TIr3)-encapsulating nanogels (IrNG) through the hyperoxidation of resulting intracellular thiols using reactive oxygen species (ROS).

Altered Glucose Metabolism and Glucose Transporters in Systemic Organs After Bariatric Surgery.

The Roux-en-Y gastric bypass (RYGB) is highly effective in the remission of obesity and associated diabetes. The mechanisms underlying obesity and type 2 diabetes mellitus remission after RYGB remain unclear. This study aimed to evaluate the changes in continuous dynamic FDG uptake patterns after RYGB and examine the correlation between glucose metabolism and its transporters in variable endocrine organs using F-fluoro-2-deoxyglucose positron emission tomography images.

Synthesis and biological evaluation of tyrosine derivatives as peripheral 5HT receptor antagonists for nonalcoholic fatty liver disease.

Non-alcoholic fatty liver disease (NAFLD), attributed to excessive fat accumulation in the liver, is reportedly prevalent worldwide. NAFLD is one of the leading causes of chronic liver disease, including non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatic cellular carcinoma (HCC). The peripheral roles of serotonin (5-hydroxytryptamine, 5HT) were found to regulate hepatic lipid metabolism.

Singlet Oxygen Generation from Polyaminoglycerol by Spin-Flip-Based Electron Transfer.

Reactive oxygen species have drawn attention owing to their strong oxidation ability. In particular, the singlet oxygen (O) produced by energy transfer is the predominant species for controlling oxidation reactions efficiently. However, conventional O generators, which rely on enhanced energy transfer, frequently suffer from poor solubility, low stability, and low biocompatibility.

A novel surgical technique to correct caudal and high dorsal septal deviations: L-shape cutting and suturing on the septal L-strut (L-septoplasty).

Objectives: In general, deviation of the L-strut of the nasal septum is more challenging to correct than the middle and has less favorable results. This study aimed to develop a technique to correct the L-strut while preserving nasal support effectively and introduce the L-septoplasty technique and its effects.

Methods: Patients with caudal and high dorsal septal deviations who underwent the L-septoplasty technique were retrospectively analyzed.

Spatial Movement Patterns and Local Co-Occurrence of Nutria Individuals in Association with Habitats Using Geo-Self-Organizing Map (Geo-SOM).

Nutrias () were imported to South Korea for farming in 1985; individuals escaped captivity and established wild populations in natural ecosystems in the late 1990s. Numerous studies have focused on their monitoring and management; however, information on the continuous movement of individuals is not available. In this study, telemetry data from field conditions were used to identify the nearest-neighbor distances of individuals in association with environmental factors, including plant type, land cover, and biological parameters.

Development of 50 InDel-based barcode system for genetic identification of tartary buckwheat resources.

Tartary buckwheat (Fagopyrum tataricum Gartn.) is a highly functional crop that is poised to be the target of many future breeding efforts. The reliable ex situ conservation of various genetic resources is essential for the modern breeding of tartary buckwheat varieties.

Selective photocatalytic production of CH using Zn-based polyoxometalate as a nonconventional CO reduction catalyst.

Efficient and selective production of CH through the CO reduction reaction (CO2RR) is a challenging task due to the high amount of energy consumption and various reaction pathways. Here, we report the synthesis of Zn-based polyoxometalate (ZnPOM) and its application in the photocatalytic CO2RR. Unlike conventional Zn-based catalysts that produce CO, ZnPOM can selectively catalyze the production of CH in the presence of an Ir-based photosensitizer (TIr3) through the photocatalytic CO2RR.

Analysing the mechanism of mitochondrial oxidation-induced cell death using a multifunctional iridium(III) photosensitiser.

Mitochondrial oxidation-induced cell death, a physiological process triggered by various cancer therapeutics to induce oxidative stress on tumours, has been challenging to investigate owing to the difficulties in generating mitochondria-specific oxidative stress and monitoring mitochondrial responses simultaneously. Accordingly, to the best of our knowledge, the relationship between mitochondrial protein oxidation via oxidative stress and the subsequent cell death-related biological phenomena has not been defined. Here, we developed a multifunctional iridium(III) photosensitiser, Ir-OA, capable of inducing substantial mitochondrial oxidative stress and monitoring the corresponding change in viscosity, polarity, and morphology.

Sino-Cutaneous Fistula After Using Medpor Implant in Orbital Blowout Fracture.

In surgical repair of orbital fracture, implant materials play an important role in restoring the functional and anatomic structure of the orbit. Alloplastic implant materials are widely used for this surgery, but they have the risk of complications such as infections, pain, and extrusion. Because they are artificial implants, infection can occur more than autologous implants and is the most challenging problem to manage.

Retraction: extract exerts an antidiabetic effect via activation of the AMP-activated protein kinase.

[This retracts the article on p. 15 in vol. 7, PMID: 23423690.

Avalanche size distribution of an integrate-and-fire neural model on complex networks.

We considered the neural avalanche dynamics of a modified integrate-and-fire model on complex networks, as well as the neural dynamics in a fully connected network, random network, small-world network, and scale-free network. We observed the self-organized criticality of the neural model on complex networks. The probability distribution of the avalanche size and lifetime follow the power law at the critical synaptic strength.

Baicalin attenuates fibrogenic process in human renal proximal tubular cells (HK-2) exposed to diabetic milieu.

Aims: Baicalin, a flavonoid glycoside substance extracted from Scutellaria baicalensis Georgi, has been shown to exhibit multiple therapeutic properties owing to its anti-inflammatory effect. Diabetes is characterized by chronic hyperglycemia, inflammation and oxidative stress, which promote renal fibrosis and kidney failure. Although anti-fibrogenic effects of baicalin in lung and liver have been reported previously, no study has investigated its roles in renal fibrosis.