Exposure to ,'-DDE Induces Morphological Changes and Activation of the PKC-p38-C/EBP Pathway in Human Promyelocytic HL-60 Cells.

Dichlorodiphenyldichloroethylene (,'-DDE), the most persistent metabolite of dichlorodiphenyltrichloroethane (DDT), is still present in the human population. Both are present in the bone marrow of patients with bone marrow disorders, but thus far there are no studies that assess the capability of ,'-DDE to affect myeloid cells. The aim of this study was to determine the effect of ,'-DDE on promyelocytic cell differentiation and intracellular pathways related to this event.