The effects of protein-rich extract from Rhizoma Gastrodiae against cerebral ischemia/reperfusion injury via regulating MAPK and PI3K/AKT signaling pathway.

Background: Rhizoma Gastrodiae is a highly valuable traditional Chinese medicine and functional health food that has been used in China to treat neurological disorders for thousands of years. Rhizoma Gastrodiae contains various of biological activities, such as antioxidative, neuroprotective, learning improvement, anxiolytic, and antidepressant effects. However, no studies have been conducted to explore the effects of the protein components in Rhizoma Gastrodiae (GEPS) and its potential protective effects against ischemic stroke.

Two new degrade triterpenoids from Levl.

Two new degrade cycloartane triterpenoids, named buboditones A, B (, ), together with ten known alkaloids, cyclobuxoviridine (), -dimethylcycloxobuxovircine (), cyclovirobuxine C (), cyclovirobuxine A (), cycloprotobuxine C (), cycloprotobuxine A (), cyclobuxoxazine (), cyclobuxoxazine A (), buxruguline B (), irehine (), were isolated from the leaves and stems of Levl., The structures of compounds were elucidated by 1 D and 2 D NMR spectroscopic methods including HSQC, HMBC, H-H COSY, NOESY, as well as HRESIMS spectroscopic analysis.

Quality Analysis of Autologous Platelet-Rich Plasmapheresis.

To summarized the technology of autologous platelet-rich plasmapheresis and analyzed the product quality, in order to provide safe and effective product guarantee service for clinical treatment. Technical parameters were set according to patient age, weight, height, and preoperative routine blood indices. Autologous platelet-rich plasma (PRP) was collected, and the product quality and adverse reactions of patients were statistically analyzed.

Double filtration plasmapheresis for hypertriglyceridemic acute pancreatitis caused by fat overload syndrome.

What Is Known And Objective: Severe hypertriglyceridemia (HTG) can cause acute pancreatitis (AP).

Case Summary: We report a patient with acute lymphoblastic leukaemia who received long-term intravenous parenteral nutrition solution without monitoring of the serum triglyceride (TG) level, which resulted in fat overload syndrome and HTG-AP.

What Is New And Conclusion: Double filtration plasmapheresis was performed to eliminate the TGs and treat the AP.

Cytotoxicity and molecular-docking approach of a new rosane-type diterpenoid from the roots of .

A new rosane-type diterpenoid () along with nine known diterpenoids (), were isolated from the dried roots of . The absolute configuration was elucidated from spectroscopic (nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, and electronic circular dichroism) and optical-rotation analyses. Cytotoxicity and the ability to scavenge 2,2-diphenyl-1-picrylhydrazyl radicals were determined.

Autologous platelet-rich plasma in the treatment of refractory wounds in cutaneous leukocytoclastic vasculitis complicated with hypertension (grade 2 moderate risk): A case report.

Introduction: Cutaneous leukocytoclastic vasculitis is an inflammatory variant of vasculitis with a variety of causes that only affects the skin. Its pathological manifestations include neutrophil infiltration and nuclear fragmentation. Clinically, it is characterised by a pleomorphic rash, including erythema, purpuric skin lesions, reticulocytosis, necrosis and ulceration.

P- Hydroxybenzyl Alcohol Alleviates Oxidative Stress in a Nonalcoholic Fatty Liver Disease Larval Zebrafish Model and a BRL-3A Hepatocyte the Nrf2 Pathway.

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and it has gradually become the main disease burden in the world. However, the pathogenesis of NAFLD is complex, involving such things as dyslipidemia, oxidative stress, inflammation, etc. This brings to the table a significant challenge for drug development, and there is still no drug approved by the FDA on the market to treat the disease.