Publications by authors named "Nako Kojima"
Article Synopsis
- The interaction between tumor cells and stromal fibroblasts is crucial for tumor progression, but the specific molecular mechanisms are still not well understood.
- A study using a 3D co-culture system showed that pancreatic cancer cells (Panc-1) not only invaded fibroblast layers but also underwent changes indicating a transition to a more invasive form when exposed to fibroblasts.
- The findings suggest that the growth factors TGF-β and HGF play significant roles in this interaction, with TGF-β inhibitors potentially enhancing cancer cell invasion in the presence of fibroblasts, indicating a complex relationship that could affect tumor progression.
