Prenatal exposure to soy and selenium reduces prostate cancer risk factors in TRAMP mice more than exposure beginning at six weeks.

Background: Diets high in soy and selenium (Se) decrease prostate cancer risk factors in healthy rats. The purpose of this study was to determine whether treatment with high levels of soy and/or supplemental Se would decrease prostate cancer risk factors in the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) mouse, and whether timing of the introduction of these nutrients would affect risk reduction.

Methods: Male hemizygous [C57BL/6 × FVB]F1 TRAMP mice were exposed to stock diets high or devoid of soy, with or without a supplement of Se-methylselenocysteine (MSC) starting at conception (10 mg Se/L in drinking water of pregnant/nursing dams; daily bolus of 4 mg Se/kg body weight to pups after weaning) or at 6 weeks of age in a 2 × 2 factorial design.

Combination effects of dietary soy and methylselenocysteine in a mouse model of prostate cancer.

Background: High dietary intake of soy or selenium (Se) is associated with decreased risk of prostate cancer. Soy constituents and various chemical forms of Se have each been shown to downregulate expression of the androgen receptor (AR) and AR-regulated genes in the prostate. We hypothesized that downregulation of AR and AR-regulated genes by the combination of these dietary components would inhibit tumorigenesis in the TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP) mouse.

Soy content of basal diets determines the effects of supplemental selenium in male mice.

The effects of supplemental Se in rodent models may depend upon composition of the basal diet to which it is added. Wild-type male littermates of Transgenic Adenocarcinoma of Mouse Prostate mice were fed until 18 wk of age 1 of 2 Se-adequate stock diets high in soy (HS) or low in phytoestrogens (LP) or the same diets supplemented with 3.0 mg Se/kg diet as seleno-methylselenocysteine.

Alertness in individuals with profound intellectual and multiple disabilities: a literature review.

Direct support persons (DSPs) often face problems in observing and determining alertness in individuals with profound intellectual and multiple disabilities (PIMD). A literature study was carried out to gather information about the problems just described. A search of two electronic databases and the references found in relevant hits revealed 42 relevant publications.

Needs, problems and rehabilitation goals of young children with cerebral palsy as formulated in the rehabilitation activities profile for children.

Objective: To describe the content of needs, problems and goals of 41 Dutch children with cerebral palsy using the International Classification of Functioning, Disability and Health for Children and Youth (ICF-CY) as a classification system. To evaluate the adherence of formulations of needs, problems and goals to specifications of the Rehabilitation Activities Profile for Children.

Methods: Raw text data were extracted and organized.

Goal setting in Dutch paediatric rehabilitation. Are the needs and principal problems of children with cerebral palsy integrated into their rehabilitation goals?

Objective: To evaluate whether the needs and principal problems of children with cerebral palsy (CP) as formulated in their interdisciplinary rehabilitation reports are integrated into the goal descriptions and whether this depends on the nature of the needs and problems.

Design: Descriptive multiple-case study.

Setting: Five Dutch paediatric rehabilitation facilities.

Adults with mild intellectual disabilities: can their reading comprehension ability be improved?

Background: Adults with a mild intellectual disability (ID) often show poor decoding and reading comprehension skills. The goal of this study was to investigate the effects of teaching text comprehension strategies to these adults. Specific research goals were to determine (1) the effects of two instruction conditions, i.

Towards integrated paediatric services in the Netherlands: a survey of views and policies on collaboration in the care for children with cerebral palsy.

Aim: Worldwide, family-centred and co-ordinated care are seen as the two most desirable and effective methods of paediatric care delivery. This study outlines current views on how team collaboration comprising professionals in paediatric rehabilitation and special education and the parents of children with disabilities should be organized, and analyses the policies of five paediatric rehabilitation settings associated with the care of 44 children with cerebral palsy (CP) in the Netherlands.

Methods: For an overview of current ideas on collaboration, written statements of professional associations in Dutch paediatric rehabilitation were examined.

Family-centred care in family-specific teams.

Objective: To evaluate the perceptions and views of parents and rehabilitation and special education professionals on the family-centredness of care delivered and received.

Design: Descriptive study with comparison of ratings in family-specific teams.

Setting: Five paediatric facilities in the Netherlands.

A review of salient elements defining team collaboration in paediatric rehabilitation.

Objective: To explicate the complex process of team collaboration and identify salient elements of team collaboration in paediatric rehabilitation.

Data Sources: After an initial search to define key features of team collaboration a systematic search on team collaboration and the key features was executed to identify salient elements. The systematic search was carried out in Index Medicus (MEDLINE), Educational Resource Information Clearinghouse (ERIC) and American Psychological Association (Psyc INFO) covering the period from January 1993 to December 2004.

Movement skill assessment in children with profound multiple disabilities: a psychometric analysis of the top down motor milestone test.

Objective: To analyse the psychometric properties of the Top Down Motor Milestone Test (TDMMT), an internationally used instrument in the planning and evaluation of movement-oriented interventions.

Setting: Centres for special education in the Netherlands.

Subjects: Children with profound multiple disabilities.

Children with profound intellectual and multiple disabilities: the effects of functional movement activities.

Objective: To determine the effect of functional movement activities within the MOVE (Mobility Opportunities Via Education) curriculum on the independence of children with profound intellectual and multiple disabilities.

Subjects: Forty-four children with profound intellectual and multiple disabilities.

Setting: Centres for special education.

Specific language impairments and behavioural problems.

The behavioural functioning of 56 children with a specific language impairment (SLI), aged 8, 10, and 12 years, was examined by using the Child Behaviour Checklist. Parents as well as teachers filled in the questionnaire. The data shows that 48% of the children with SLI were considered to have behavioural problems either at home or in school.

Research on a psychomotor program for children with severe motor or multiple disabilities.

This report deals with help for brain-injured children with severe motor or multiple disabilities. It is argued that these children lack experiences due to their motor-disabilities. On the basis of an analysis of psychomotor programs the program by Le Gay Brereton was chosen for further research.