Publications by authors named "Nakita Antao"
Org Process Res Dev
January 2017
Article Synopsis
- A scalable synthesis process for the preclinical drug candidate DNDI-VL-2098, aimed at treating visceral leishmaniasis, is outlined.
- The synthesis involves a four-step method, including the Sharpless asymmetric epoxidation of 2-methyl-2-propen-1-ol and utilizes retrosynthetic analysis to optimize the route.
- The process is streamlined by using in situ synthesis for intermediates, which enhances safety and eliminates the need for column chromatography, resulting in high yields and purity on a kilogram scale.
