Incorporation of metallic-organic frameworks into chitosan/hyaluronic acid nano-fibrous scaffold; antimicrobial and non-cytotoxicity evaluation.

This study presents the development of an enhanced wound dressing utilizing electrospun chitosan/polyvinyl alcohol/hyaluronic acid (CS/PVA/HA) nanofibers combined with copper-based metal-organic frameworks (MOFs) and silver nanoparticles (AgNPs). The primary aim was to create a dressing that supports skin regeneration while exhibiting antimicrobial properties and moisture absorption capabilities. HKUST-1 MOFs were synthesized via a solvothermal method and subsequently integrated with AgNPs into the CS/PVA/HA matrix.