Induced seismicity and geothermal energy production in the Salton Sea Geothermal Field, California.

We analyze the relationship between geothermal energy production and seismic hazards in the Salton Sea Geothermal Field (SSGF) between 1972 and 2022. A clear increase in seismic activity accompanies geothermal energy production and is greatest to the east of the Brawley fault, where the amount of injection exceeds the amount of production. We estimate that, whereas there was a 2% chance of a M6.

Using artificial intelligence and promoter-level transcriptome analysis to identify a biomarker as a possible prognostic predictor of cardiac complications in male patients with Fabry disease.

Fabry disease is the most frequently occurring form of lysosomal disease in Japan, and is characterized by a wide variety of conditions. Primarily, the three major types of concerns associated with Fabry disease observed during adulthood that must be prevented are central nervous system, renal, and cardiac complications. Cardiac complications, such as cardiomyopathy, cardiac muscle fibrosis, and severe arrhythmia, are the most common mortality causes in patients with Fabry disease.

Silyliumylidene Ion Stabilized by Two σ-Donating Ni(0)- and Pd(0)-Fragments.

A silyliumylidene ion 2 stabilized by two σ-donating Ni(0)- and Pd(0)-fragments was successfully synthesized. Due to the σ-donation of M→Si interactions, 2 presents a pyramidalized cationic silicon center with a localized lone pair. The additional coordination of basic Pd(0) fragment to the mono-Ni(0)-stabilized silyliumylidene 1 results in a higher HOMO level and an unchanged HOMO-LUMO gap and thus, 2 remains highly reactive.

Syntheses of Iminophosphomamido Chlorogermylenes and Their Complexation with a Rhodium(I) Complex.

Three-coordinated chlorogermylenes of the type [Ph P(RN) ]GeCl (3: R= Bu; 4: R=Dip=2,6- Pr C H ), which bear an N,N-substituted iminophosphonamide ligand, were synthesized. The coordination behavior of 3 and 4 toward rhodium(I) complex was investigated. When 3 was treated with 1/2 of an equivalent of [RhCl(cod)] (cod=1,5-cyclooctadiene), the corresponding chlorogermylene-Rh(I) complex 5 was obtained as orange crystals.

Molecular mechanism of the common and opposing cosolvent effects of fluorinated alcohol and urea on a coiled coil protein.

Alcohols and urea are widely used as effective protein denaturants. Among monohydric alcohols, 2,2,2-trifluoroethanol (TFE) has large cosolvent effects as a helix stabilizer in proteins. In contrast, urea efficiently denatures ordered native structures, including helices, into coils.

Synthesis of a homoleptic tris(silylene)-palladium(0) complex and a silylyne-bridged tetranuclear palladium cluster.

We report the reactions of an iminophosphonamido-silylene (1) with different palladium complexes. The reaction of 1 with [Pd(PPh)] furnished a homoleptic tris(silylene)-palladium(0) complex. In contrast, treatment of 1 with [PdMe(tmeda)] led to the unprecedented formation of a non-planar -silylyne-bridged tetranuclear palladium cluster that contains palladium atoms in different oxidation states.

Having cake and eating too: The benefits of an intermediate larval form in a brittle star sp. opaque (Ophiuroidea).

Most marine invertebrate larvae either obligately feed or depend on maternally provided reserves during planktonic development. A small number of species have the capacity to do both, in a mode of development known as facultative planktotrophy. We describe facultative feeding in a larva from the Oregon coast, and identify it as being an undescribed species in the genus , which we refer to as sp.

Niobium Complexes Supported by Chalcogen-Bridged [OEO]-Type Bis(phenolate) Ligands (E = S, Se): Synthesis, Characterization, and Phenylacetylene Polymerization.

Trichloro niobium(V) complexes and with the sulfur- or selenium-bridged [OEO]-type bis(phenolate) ligands (E = S, Se) were synthesized and fully characterized on the basis of their NMR spectroscopic data and X-ray crystallographic analysis. In the crystalline state of , the [OSeO]-core of the ligand was coordinated to the niobium center in a -fashion. The corresponding tribenzyl niobium(V) complexes and were also prepared by the reactions of and with 3 equivalents of PhCHMgCl in toluene.

Ensemble Learning of Multiple Models Using Deep Learning for Multiclass Classification of Ultrasound Images of Hepatic Masses.

Ultrasound (US) is often used to diagnose liver masses. Ensemble learning has recently been commonly used for image classification, but its detailed methods are not fully optimized. The purpose of this study is to investigate the usefulness and comparison of some ensemble learning and ensemble pruning techniques using multiple convolutional neural network (CNN) trained models for image classification of liver masses in US images.

In vitro study about prevention of vascular reocclusion by low intensity ultrasonic irradiation.

For the treatment of acute ischemic stroke, the current standard of care is thrombolysis by the administration of intravenous (IV) recombinant tissue-type plasminogen activator (rt-PA). Although this approach is proven to be effective, reocclusion within 24 hours occurs in about 20% of patients who receive recanalization by rt-PA. In addition, the administration of anticoagulants within 24 hours after IV rt-PA increases the risk of intracranial hemorrhage; therefore, treatment with anticoagulants is contraindicated in this population.

Iminophosphonamido-Supported Plumbylenes and Plumbyliumylidenes: Synthesis and Properties.

A series of low-valent lead(II) species, i.e., plumbylenes and plumbyliumylidenes supported by an ,'-di--butyliminophosphonamide ligand, have been synthesized.

Detection of Sacral Fractures on Radiographs Using Artificial Intelligence.

Unlabelled: Sacral fractures are often difficult to diagnose on radiographs. Computed tomography (CT) and magnetic resonance imaging (MRI) can improve the detection rate but cannot always be performed. The accuracy of artificial intelligence (AI) in detecting orthopaedic fractures is now comparable with that of orthopaedic specialists.

Efficient Cell Impedance Measurement by Dielectrophoretic Cell Accumulation and Evaluation of Chondrogenic Phenotypes.

The quantitative and functional analyses of cells are important for cell-based therapies. In this study, to establish the quantitative cell analysis method, we propose an impedance measurement method supported by dielectrophoretic cell accumulation. An impedance measurement and dielectrophoresis device was constructed using opposing comb-shaped electrodes.

Halogen-Exchange Reactions of Iminophosphonamido-Chlorosilylenes with Alkali Halides: Convenient Synthesis of Heavier Halosilylenes.

Halogen-substituted silylenes are an important building block for synthesizing silicon-based low-valent and multiple-bond species. However, the number of reports on heavier halosilylenes that contain bromine and iodine is still limited. Here, we present a convenient synthesis for bromo- and iodosilylenes supported by an iminophosphonamide ligand.

Radiation dosimetry and efficacy of an Zr/Ac-labeled humanized anti-MUC5AC antibody.

Introduction: Theranostic applications are currently difficult to achieve owing to the limited evaluation of suitable chelators for therapeutic nuclides, such as Ac and Th. With a focus on targeted α therapy and theranostics using human IgG as a drug-delivery system (i.e.

Hydroboration of carbonyls and imines by an iminophosphonamido tin(II) precatalyst.

A novel three-coordinated tin(II) chloride [PhP(NBu)]SnCl (1) supported by an ,'-di--butyliminophosphonamide having two phenyl groups on the phosphorus atom was synthesized by the reaction of the starting lithium iminophosphonamide [PhP(NBu)]Li with SnCl·(dioxane) in toluene. The molecular structure of 1 was established by X-ray diffraction analysis. Tin(II) chloride 1 can act as an efficient precatalyst for the hydroboration of a wide variety of aldehydes, ketones, and imines at -10 °C.

Simultaneous Determination of Mycobacterium leprae Drug Resistance and Single-Nucleotide Polymorphism Genotype by Use of Nested Multiplex PCR with Amplicon Sequencing.

Mycobacterium leprae is the predominant cause of leprosy worldwide, and its genotypes can be classified into four single-nucleotide polymorphism (SNP) types and 16 subtypes. Determining M. leprae drug resistance and genotype is typically done by PCR and Sanger DNA sequencing, which require substantial effort.

Formation of silaimines from a sterically demanding iminophosphonamido chlorosilylene intramolecular N-P bond cleavage.

The sterically demanding iminophosphonamido chlorosilylene [Ph2P(DipN)2]SiCl (Dip = 2,6-diisopropylphenyl) was synthesized and fully characterized using NMR spectroscopy and X-ray crystallography. Substitution reactions of [Ph2P(DipN)2]SiCl with N- and Fe-nucleophiles led to the unexpected formation of the corresponding silaimine derivatives. This process involves the ring-opening rearrangement of three-coordinated silylene intermediates that proceeds via intramolecular N-P bond cleavage.

Strained and Reactive Donor/Acceptor-Supported Metallasilanone.

A novel stable donor/acceptor-supported Mn -metallasilanone 3 was synthesized. The intramolecular silanone-Mn interaction induces a highly strained three-membered cyclic structure, leading to an exceptionally high reactivity of 3 as a donor/acceptor complex of silanone. Indeed, metallasilanone 3 readily reacts with various small molecules such as H or ethylene gas in mild conditions.

Interconversion between a silaimine and an aminosilylene supported by an iminophosphonamide ligand.

The reaction of a chlorosilylene, supported by an iminophosphonamide ligand, with KN(SiMe) resulted in the formation of a silaimine instead of the expected aminosilylene. However, this silaimine exists in equilibrium with the corresponding aminosilylene, which was experimentally demonstrated using variable-temperature NMR spectroscopy and a trapping reaction with elemental selenium to give a silaselenourea.

Coexpression of MmpS5 and MmpL5 Contributes to Both Efflux Transporter MmpL5 Trimerization and Drug Resistance in Mycobacterium tuberculosis.

The increasing occurrence of multidrug-resistant () is a serious threat to global public health. Among the many mechanisms of drug resistance, only resistance-nodulation-division (RND)-type multidrug efflux systems can simultaneously render bacteria tolerant to numerous toxic compounds, including antibiotics. The elevated expression of RND-type xenobiotic efflux transporter complexes, which consist of an inner membrane transporter, membrane fusion protein, and outer membrane channel, plays a major role in multidrug resistance.

Point mutation in the stop codon of increases the growth rate of subspecies .

subspecies (MAH) is a pathogen that causes various non-tuberculous mycobacterial diseases in humans and animals worldwide. Among the genus, MAH is characterized by relatively slow growth. Here, we isolated a rapidly growing variant of the MAH 104 strain.

An Iminophosphonamido-Chlorosilylene as a Strong σ-Donating NHSi Ligand: Synthesis and Coordination Chemistry.

The N-heterocyclic silylene (NHSi) [Ph P( BuN) ]SiCl (1), supported by an iminophosphonamide ligand, was obtained from the dehydrochlorination of [Ph P( BuN) ]SiHCl (2) with LiN(SiMe ) . NHSi 1 contains an extremely high-energy HOMO level and consequently displays unique coordination behavior toward Rh complexes. When 1 was treated with 1/4 of an equivalent of [RhCl(cod)] (cod=1,5-cyclooctadiene), the 14-electron Y-shaped bis(chlorosilylene) Rh complex 5 was obtained as dark purple crystals.

Disseminated Mycobacterium massiliense infection in a patient with myelodysplastic syndrome undergoing allogeneic bone marrow transplantation.

Nontuberculous mycobacteria are ubiquitous in water and soil, and the subset of rapidly growing mycobacteria species can cause severe infections in immunocompromised patients. Solid organ or hematopoietic stem cell transplantation (HSCT) recipients are known to be susceptible to infection by nontuberculous mycobacteria. The nontuberculous mycobacteria species Mycobacterium massiliense (M massiliense) has been classified as a rapidly growing mycobacteria and recognized as a pathogen causing lung and soft tissue infections in humans.