Suppression of defense gene expression under nutrient-rich condition in seedlings.

Plant hormones like salicylic acid (SA) and jasmonic acid (JA) play crucial roles in regulating defense gene expression systems. SA mainly regulates defense against biotrophic pathogens, while JA mediates defense against necrotrophic pathogens. Compounds called plant activators including probenazole, acibenzolar-s-methyl and 2,6-dichloroisonicotinic acid (INA) activate plant immune systems, providing protection against pathogens.

An evaluation of the modified carbapenem inactivation method (mCIM) in conjunction with EDTA or sodium mercaptoacetate, for detecting metallo β-lactamase production for Aeromonas species harboring bla.

Several Aeromonas species, including Aeromonas hydrophila, have been known to produce CphA, a chromosomal metallo β-lactamase (MBL). We aimed to evaluate the clinical usefulness of modified carbapenem inactivation method (mCIM) in conjunction with EDTA (eCIM) or sodium mercaptoacetate (SMA-mCIM) for MBL-producing Aeromonas species. Fifty-six clinical isolates of Aeromonas species stored at the University of the Ryukyus Hospital were used in this study.

Obstructive sleep Apnoea in patients with knee osteoarthritis before total knee arthroplasty and its impact on post-operative recovery of blood oxygen concentrations.

Introduction: Post-operative delays in blood oxygen recovery are sometimes observed after total knee arthroplasty (TKA), with obstructive sleep apnoea (OSA) being a contributing factor. This study aimed to examine the prevalence of OSA and its correlation with post-operative oxygen saturation (SpO2) recovery in patients undergoing TKA for knee osteoarthritis (OA).

Materials And Methods: This was an observational case-control study including patients with knee OA who underwent TKA between January 2018 and October 2021.

Acetic Acid-Indigo Carmine Chromocolonoscopy for Proximal Serrated Lesions: A Randomized, Three-Arm Colonoscopy Study.

Objectives: Aggressive colorectal cancer (CRC) frequently originates from serrated lesions (SLs), particularly in the proximal colon, which are challenging to detect using standard screening colonoscopy. Although duplicate examinations or chromocolonoscopies are recommended for detecting proximal SLs, evidence from randomized trials is limited. We evaluated the effectiveness of tandem colonoscopy with an acetic acid-indigo carmine mixture (AIM) for detecting SLs in the proximal colon compared to white-light imaging (WLI) and indigo carmine (IC).

Application of chlorous acid water for disinfection of surgical site in dairy cows.

Disinfection is crucial for preventing surgical site infections. Recently, the effectiveness of sanitizers using chlorous acid (HClO) under conditions rich in organic matter has been reported, and chlorous acid water (CAW) has been approved as a food additive. This study evaluated the potential of CAW as a new presurgical disinfectant for cattle.

Differences in Tolerability of Antifibrotic Agents Between Connective Tissue Disease-Associated and Non-connective Tissue Disease-Associated Interstitial Lung Disease.

Background Although antifibrotic agents (AFAs) are often discontinued due to side effects, their tolerability is crucial given the limited treatment options for interstitial lung disease associated with connective tissue disease (CTD-ILD). The possibility of intolerance due to organ damage caused by CTDs has also been considered; however, few detailed studies are available. We hypothesized that AFAs for CTD-ILD would be poorly tolerated or discontinued prematurely due to organ damage caused by collagen disease.

A Spiro-Driven Ferroelectric Coordination Polymer Exhibiting Distinct Phase Transitions under Thermal and Pressure Stimuli.

Controllable strategies for the design of molecular ferroelectrics have been actively pursued in recent years due to their promising applications in modern electronic devices. In this work, we present a spiro-driven approach for the design of a new class of molecular ferroelectrics. Using 2-morpholinoethanol (MEO) as a bidentate chelating ligand and the SCN- anion as a bridging co-ligand, we obtained a neutral chain-like ferroelectric coordination polymer, [Cd(MEO)(SCN)2].

Development of a novel anti-erythropoietin-producing hepatocellular receptor B6 monoclonal antibody EbMab-3 for flow cytometry.

Erythropoietin-producing hepatocellular receptor B6 (EphB6) is a member of the largest Eph subfamily of receptor tyrosine kinases. EphB6 is widely expressed in various tissues and regulates cellular homeostasis by interacting with its membrane-bound ephrin ligands and other receptors. EphB6 is involved in cancer pathology despite lacking kinase activity.

Detection Thresholds for Replay and Real-Time Discrepancies in VR Hand Redirection.

Hand redirection, which subtly adjusts a user's hand movements in a virtual environment, can modify perception and movement by providing real-time corrections to motor feedback. In the context of motor learning and rehabilitation, observing replays of movements has been shown to enhance motor function. The application of hand redirection to these replays by making movements appear larger or smaller than they actually are has the potential to improve motor function.

A Case of Bacteremia and Septic Thrombophlebitis Caused by an Infusion Set Contaminated with Bacillus cereus.

A 48-year-old man with Fisher syndrome was admitted to our hospital for amino acid-containing peripheral parenteral nutrition. On day 19 of his hospital stay, he became febrile and Bacillus cereus was isolated from blood cultures. Vancomycin was administered, and the entire infusion set was replaced.

Association Between Human Milk Oligosaccharides and Early Adiposity Rebound in Children: A Case-Control Study of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Background: Adiposity rebound (AR) is the point when the body mass index (BMI) begins to rise again during early childhood. Early AR (before age 5) is associated with a higher risk of lifelong obesity and metabolic disorders and may be influenced by breastfeeding. Although human milk oligosaccharides (HMOs) in breast milk are crucial for child growth, their association with AR status has not been studied.

Nanothin Descemet stripping automated endothelial keratoplasty performed on a lacerated cornea after globe rupture: a case report.

Background: When performing corneal endothelial transplantation, the presence of low intraocular pressure, abnormal host corneal shape, and septal defects between the anterior and posterior chamber may cause poor graft adhesion. We report our experience with Descemet stripping automated endothelial keratoplasty (DSAEK) using a nanothin graft in a case of bullous keratopathy (BK) in a lacerated cornea after globe rupture-a situation that encompasses these risk factors.

Case Presentation: An 81-year-old man was admitted to our department after he had ruptured his right eyeball following a fall.

Flash grab effect within the regions of modal and amodal completions.

When a rotating grating reverses its direction and is accompanied by a briefly flashed stimulus on top, the flash's apparent position shifts in direction after the reversal. This phenomenon, termed the flash-grab effect, can induce an illusory position shift of several degrees of visual angle, prompting investigation into scenarios in which the expected position coincides with another visual event. We investigated two such situations: perceptual filling-in at the blind spot and amodal completion behind a visible occluder.

Pseudo[3]rotaxane and [3]Rotaxane of Per(5-carboxy-5-dehydroxymethyl)-Cyclodextrins Utilizing Carboxylic Acid Dimer as Recognition Units.

The formation of pseudo[3]rotaxane using dimers of per(5-carboxy-5-dehydroxymethyl)-cyclodextrins as ring components and secondary ammoniums as an axle is presented. This supramolecule is formed by the unique interaction of circularly arranged carboxylic acid dimers acting as hydrogen bonding acceptors covering the axle moiety. On these grounds, we could achieve the synthesis of the [3]rotaxane by capping the terminal groups through thiol-ene reactions.

Remote Rehabilitation System Capable of Sharing Somatosensory Sensations.

Elderly individuals may develop health issues related to the decline in motor function as they age, often requiring rehabilitation to improve their mobility. In order to provide high-quality rehabilitation to a larger population, this study aims to develop remote rehabilitation technology that allows for the sharing of somatosensory sensations. To facilitate the sharing of somatosensory sensations, wearable technology capable of posture acquisition and force feedback, as well as a sensor mannequin capable of capturing touch patterns, were developed.

Coral Decline Linked to Exchangeable Phosphate in Seawater from Coastal Calcareous Sediments, as Evidenced in Sekisei Lagoon, Japan.

Coral reefs are essential for biodiversity and ecosystem services, yet they face threats like bleaching and reduced resilience due to rising seawater temperatures and land-based pollution. This study examined phosphate accumulation in calcareous sediments and its relationship with coral populations in Sekisei Lagoon, Okinawa Islands, Japan. Sediment samples from 117 sites were analyzed for exchangeable phosphate in seawater (EPS), which could be released from the calcareous sediments.

Comparative surgical invasiveness of internal fixation for pathological fractures in metastatic bone disease versus traumatic fractures: a quantitative analysis of operative time and blood loss.

Objective: The primary aim of this study was to compare the surgical invasiveness of internal fixation for pathological fractures caused by metastatic bone tumors with that for traumatic fractures. The secondary aim was to identify factors contributing to the complexity of surgeries for metastatic bone disease and provide insights for improving surgical strategies by analyzing operative time and blood loss.

Methods: Patients undergoing internal fixation for femoral fractures at 10 institutions between January 2021 and December 2023 were included.

Early Rehabilitation Interventions by Physical Therapists for Severe COVID-19 Patients Were Associated With Decreased Incidence of Post-ICU Physical Impairment.

Objective: To implement early rehabilitation interventions by physical therapists is recommended. However, the effectiveness of early rehabilitation for severe coronavirus disease 2019 (COVID-19) patients in the prevention of post-intensive care syndrome (PICS) is unclear. We analyzed a multicenter prospective observational study (Post-Intensive Care outcomeS in patients with COronaVIrus Disease 2019) to examine the association between early rehabilitation interventions and PICS physical impairment.

Mid-Range Paced-QRS as an Independent Negative Predictor of Cardiac Events - Right Ventricular Pacing Implications.

Background: The effect of paced-QRS (p-QRS) duration on long-term outcomes is unclear, so we assessed the association between p-QRS duration and cardiac events.

Methods And Results: We enrolled 187 patients (103 males, mean age: 77±12 years) who underwent pacemaker implantation between 2018 and 2021. During the median follow-up period of 972 days (761-1,292 days), 18 patients experienced cardiac events (1 cardiac death, 17 heart failure hospitalizations).

Spatial and temporal variations in coral reef recovery amid recurring bleaching events in Okinawa Island, Japan.

Climate change is altering coral reefs around the world at an unprecedented rate, with increasing frequency and magnitude of mass bleaching events caused by high sea surface temperatures (SSTs). In this study, we examined coral communities through reef transect surveys at two depth zones (1-5m and 7-12m) across 11 sites on Okinawa Island, Japan. This study focused on trends in coral cover and composition in Okinawa Island, particularly following the thermal stress events of 2017 and 2022 and the high SSTs of 2023.

S-Nitrosylation of CRTC1 in Alzheimer's disease impairs CREB-dependent gene expression induced by neuronal activity.

cAMP response element-binding protein (CREB)-regulated transcription coactivator 1 (CRTC1) plays an important role in synaptic plasticity, learning, and long-term memory formation through the regulation of neuronal activity-dependent gene expression, and CRTC1 dysregulation is implicated in Alzheimer's disease (AD). Here, we show that increased S-nitrosylation of CRTC1 (forming SNO-CRTC1), as seen in cell-based, animal-based, and human-induced pluripotent stem cell (hiPSC)-derived cerebrocortical neuron-based AD models, disrupts its binding with CREB and diminishes the activity-dependent gene expression mediated by the CRTC1/CREB pathway. We identified Cys216 of CRTC1 as the primary target of S-nitrosylation by nitric oxide (NO)-related species.

Confronting Upside-Down Video-Assisted Thoracic Surgery Approach for Hemorrhagic Bronchogenic Cyst Manifested by Sudden Back Pain.

Introduction: Bronchogenic cysts, arising from an aberrant bronchial primordium inclusion during the fetal period, are typically located in the mediastinum but can develop in ectopic regions. While generally asymptomatic, these cysts may become symptomatic due to infection or, rarely, hemorrhage. This report details a case of a hemorrhagic bronchogenic cyst in the supradiaphragmatic region, successfully resected using video-assisted thoracic surgery (VATS) with a confronting upside-down monitor setting.

Short- and Long-term Surgical Results of Extended Surgery for Widespread Gallbladder Carcinoma.

Background/aim: Hepatectomy with extrahepatic bile duct resection (Hx+EBDR), pancreaticoduodenectomy (PD), and occasionally hepatopancreaticoduodenectomy (HPD) are required for the treatment of advanced gallbladder cancer (GBC). This study aimed to clarify the clinical value of these extended surgeries for GBC.

Patients And Methods: We retrospectively reviewed the medical records of patients who underwent curative resection (Surg-G, n=59), and their survival rates were compared with those of patients with unresectable GBC who underwent chemotherapy (CTx-G, n=63).