Publications by authors named "Nakamori S"
Background: Risk stratification for sudden cardiac death (SCD) in patients with nonischemic cardiomyopathy (NICM) remains challenging.
Objectives: This study aimed to investigate the impact of epicardial adipose tissue (EAT) on SCD in NICM patients.
Methods: Our study cohort included 173 consecutive patients (age 53 ± 14 years, 73% men) scheduled for primary prevention implantable cardioverter-defibrillators (ICDs) implantation who underwent preimplant cardiovascular magnetic resonance.
Article Synopsis
- * A biopsy confirmed the presence of mucinous carcinoma with a Gleason score of 4+3=7, indicating a moderately aggressive cancer, and the disease was classified as stage cT3bN0M0.
- * After undergoing robotic surgery for prostate removal and lymph node dissection, follow-up showed no signs of cancer recurrence, suggesting that surgery can lead to a favorable outcome for patients with this aggressive form of prostate cancer.
Article Synopsis
- A study was conducted to evaluate the outcomes of colorectal cancer patients who underwent either partial or total cystectomy due to bladder invasion, analyzing both oncological and functional results.
- Out of 107 patients, most underwent partial resection, with significant differences in bladder invasion rates and post-surgery complications between the two groups.
- Results showed that while partial cystectomy had a lower urinary-specific morbidity rate and better bladder function preservation, both procedures had similar long-term cancer recurrence rates.
Background: The effects of myocarditis after mRNA COVID-19 vaccination (mCV) on myocardial tissue, and the association between cardiomyocyte injury and clinical presentation, are not fully understood.
Methods And Results: We retrospectively registered patients clinically diagnosed with myocarditis after the first or second mCV who underwent endomyocardial biopsy or autopsy from 42 participating centers in Japan. We investigated the histological features and their association with clinical presentation based on cardiomyocyte injury.
Article Synopsis
- The study compared the incidence of incisional hernias in patients who had their surgical specimen removed through two different incisions: Pfannenstiel incision (PI) and midline incision (MI).
- A total of 370 patients were analyzed, and after adjusting for variables using propensity score matching, 71 patients from each group were compared, revealing that the PI method had no hernia cases while the MI method had a 14% incidence.
- The findings suggest that using the PI for specimen extraction is better due to the significantly lower occurrence of incisional hernias and no increase in complication rates.
Article Synopsis
- The study found that in patients with hypertrophic cardiomyopathy (HCM), younger individuals (ages 20-59) experience a higher rate of late gadolinium enhancement (LGE) progression compared to older adults (≥60 years).
- Out of 102 patients, 87% of those with initial LGE showed increased levels over an average follow-up of 3.7 years, with young patients showing nearly four times the risk of progressing LGE at a rate of ≥1% per year.
- Significant predictors for this progression included being under 60 years old and having an initial LGE extent of ≥10%.
This study established an Orthogonal Partial Least Squares (OPLS) model combining H-NMR and GC-MS data to identify characteristic metabolites in complex extracts. Both in metabolomics studies, and natural product chemistry, the reliable identification of marker metabolites usually requires laborious isolation and purification steps, which remains a bottleneck in many studies. Both ginger (GR) and processed ginger (PGR) are listed in the Japanese pharmacopeia.
View Article and Find Full Text PDFBackground: Clinical significance of an integrated evaluation of epicardial adipose tissue (EAT) and the right ventricle (RV) in heart failure with preserved ejection fraction (HFpEF) is unknown.
Objectives: The authors investigated the potential of EAT and RV quantification for obesity-related pathophysiology and risk stratification in obese HFpEF patients using cardiovascular magnetic resonance (CMR).
Methods: A total of 150 patients (obese, body mass index ≥30 kg/m; n = 73, nonobese, body mass index <30 kg/m; n = 77) with a clinical diagnosis of HFpEF undergoing CMR were retrospectively identified.
Article Synopsis
- The study aimed to see if cardiovascular magnetic resonance radiomics can differentiate between noncollagen and inflammatory extracellular space from collagen in patients with dilated cardiomyopathy.
- Researchers analyzed data from 132 patients who had undergone heart imaging and a biopsy, calculating various radiomic features and using principal component analysis to narrow them down for better diagnostic accuracy.
- Results showed four distinct histopathological groups, revealing that noncollagenous extracellular space expansion had the strongest link to myocardial inflammation, and using radiomics improved the differentiation between types of extracellular space compared to traditional imaging methods.
Article Synopsis
- * A total of 493 patients were analyzed, revealing that lateral pelvic recurrence occurred in 5.5%, with certain factors like age, lateral lymph node metastasis, and chemotherapy influencing recurrence risks.
- * The findings highlighted both the effectiveness and limitations of lateral lymph node dissection, stressing its importance as a surgical technique for managing advanced rectal cancer.
Deformation-encoding Deep Learning Transformer for High-Frame-Rate Cardiac Cine MRI.
Radiol Cardiothorac Imaging
June 2024
Purpose To develop a deep learning model for increasing cardiac cine frame rate while maintaining spatial resolution and scan time. Materials and Methods A transformer-based model was trained and tested on a retrospective sample of cine images from 5840 patients (mean age, 55 years ± 19 [SD]; 3527 male patients) referred for clinical cardiac MRI from 2003 to 2021 at nine centers; images were acquired using 1.5- and 3-T scanners from three vendors.
View Article and Find Full Text PDFBackground: Lynch-like syndrome (LLS) has recently been proposed as a third type of microsatellite instability (MSI) tumor after Lynch syndrome (LS) and sporadic MSI colorectal cancer (CRC) without either a germline variant of mismatch repair (MMR) genes or hypermethylation of the MLH1 gene. The present study aimed to clarify and compare the clinicopathological characteristics of LLS with those of the other MSI CRC subtypes.
Methods: In total, 2634 consecutive patients with CRC who underwent surgical resection and subsequently received universal tumor screening (UTS), including MSI analysis were enrolled between January 2008 and November 2019.
Hazard function analysis of prognosis after recurrent colorectal cancer.
Langenbecks Arch Surg
April 2024
Article Synopsis
- This study focuses on evaluating the prognosis of patients who experience a recurrence of colorectal cancer (CRC) by using hazard function analysis (HFA) instead of just mean survival time (MST).
- It analyzed the medical records of 725 patients post-surgery and found a five-year survival rate of 37.8% and an MST of 3.5 years, highlighting that the death risk peaked around 2.9 years after recurrence.
- Seven key factors were identified that could predict shorter survival, and the findings reveal significant differences in MST and survival rates based on factors like the number of metastatic organs and treatment approaches.
Article Synopsis
- - The study introduces the neoadjuvant rectal (NAR) score as a superior prognostic model compared to traditional TNM classification for rectal cancer patients post-chemoradiotherapy, integrating a new technique for assessing tumor apoptosis.
- - A retrospective analysis of 319 patients showed that the modified NAR score outperformed other models, including the modified TNM score, in predicting both recurrence-free and overall survival, with the highest C-index and lowest Akaike's information criterion.
- - The results support the use of this novel prognostic model that combines apoptosis detection with the NAR score, offering better insights into the prognosis of rectal cancer patients after chemoradiotherapy.
Background: Left ventricular ejection fraction (LVEF) is the most commonly clinically used imaging parameter for assessing cancer therapy-related cardiac dysfunction (CTRCD). However, LVEF declines may occur late, after substantial injury. This study sought to investigate cardiovascular magnetic resonance (CMR) imaging markers of subclinical cardiac injury in a miniature swine model.
View Article and Find Full Text PDFArticle Synopsis
- Oxaliplatin-based chemotherapy is commonly used after colorectal cancer surgery, but it can lead to adverse effects like blue liver and localized peliosis hepatis, which may mimic metastatic tumors.
- A case study describes a 50-year-old male patient who, after surgery and chemotherapy for rectosigmoid colon cancer, developed a low-density liver area that was initially diagnosed as a metastatic tumor.
- Histopathological analysis of the resected lesion revealed severe sinusoidal dilation, confirming the diagnosis of localized peliosis hepatis rather than a metastatic tumor, underscoring the challenges in distinguishing these conditions through imaging.
Article Synopsis
- The study addresses the challenges of managing colorectal polyp burden in patients with familial adenomatous polyposis (FAP) and explores the potential of tailoring management strategies based on genetic types (genotypes).
- Using data from a Japanese multicenter study, the research evaluates the risk of colorectal cancer (CRC) associated with two different genotype groups: Genotype-1 and Genotype-2.
- Findings indicate patients with Genotype-1 have a significantly lower risk of advanced CRC compared to Genotype-2, suggesting the need for genotype-specific approaches in clinical management, which require further validation through future studies.
Background: Exercise cardiovascular magnetic resonance (Ex-CMR) myocardial tagging would enable quantification of myocardial deformation after exercise. However, current electrocardiogram (ECG)-segmented sequences are limited for Ex-CMR.
Methods: We developed a highly accelerated balanced steady-state free-precession real-time tagging technique for 3 T.
Gadolinium-Free Cardiac MRI Myocardial Scar Detection by 4D Convolution Factorization.
Med Image Comput Comput Assist Interv
October 2023
Gadolinium-based contrast agents are commonly used in cardiac magnetic resonance (CMR) imaging to characterize myocardial scar tissue. Recent works using deep learning have shown the promise of contrast-free short-axis cine images to detect scars based on wall motion abnormalities (WMA) in ischemic patients. However, WMA can occur in patients without a scar.
View Article and Find Full Text PDFPurpose: The purposes of this study were to compare global coronary flow reserve (CFR) between patients with idiopathic dilated cardiomyopathy (DCM) and risk-matched controls using cardiac MRI (CMR), and to evaluate the relationship between global CFR and CMR left ventricular (LV) parameters.
Methods: Twenty-six patients with DCM and 26 risk-matched controls who underwent comprehensive CMR examination, including stress-rest coronary sinus flow measurement by phase contrast (PC) cine CMR were retrospectively studied. LV peak global longitudinal, radial, and circumferential strains (GLS, GRS, and GCS) were determined by feature tracking.
Background: Late gadolinium enhancement (LGE) scar burden by cardiac magnetic resonance is a major risk factor for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). However, there is currently limited data on the incremental prognostic value of integrating myocardial LGE radiomics (ie, shape and texture features) into SCD risk stratification models.
Objectives: The purpose of this study was to investigate the incremental prognostic value of myocardial LGE radiomics beyond current European Society of Cardiology (ESC) and American College of Cardiology (ACC)/American Heart Association (AHA) models for SCD risk prediction in HCM.
Article Synopsis
- Developed a deep learning model for improving cardiac cine imaging by combining with techniques like parallel imaging and compressed sensing.
- The model was trained on over 1600 patient images and tested on 181 participants to restore spatial resolution in both breath-hold and real-time cine images.
- Results showed that the deep learning model achieved similar or better diagnostic quality and reduced artifacts compared to traditional methods, allowing for more efficient image acquisition.