Additional evidence on the phenotype produced by combination of 1677delTA alleles and their relevance in causing CFTR-related disease.

Cystic fibrosis is the most common, life-threatening, autosomal recessive disease in the Caucasian population. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator gene, which encodes a chloride ion channel expressed on the surface of epithelial cells. There are more than 2000 variants of the cystic fibrosis transmembrane conductance regulator gene reported worldwide.

Bacteriophage Therapy as a Potential Management Option for Surgical Wound Infections.

To investigate the potential role of bacteriophages in the treatment of surgical infections, we conducted a retrospective analysis of four surgical patients who have sought treatment at the Eliava Phage Therapy Center, Tbilisi, Georgia. Two patients had chronic osteomyelitis, one presented with a diabetic foot ulcer, and the fourth patient had developed a severe infectious complication after skin grafting surgery. Patients were treated with different combinations of bacteriophage preparations, based on the sensitivity of the isolated bacterial strain toward commercially available bacteriophages.

Influence of the geroprotector 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride on the lifetime of Drosophila melanogaster.

A slowdown of the aging process was established in Drosophila melanogaster than received the geroprotector 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride. The action of the preparation in a dose of 0.01% at the larval stage of development leads to an 18--20% increase in the average lifetime of females and males and lengthens the maximum lifespan of males.