Improvement of an encapsulation process for the preparation of pro- and prebiotics-loaded bioadhesive microparticles by using experimental design.

The purpose of this study was to design a new vaginal bioadhesive delivery system based on pectinate-hyaluronic acid microparticles for probiotics and prebiotics encapsulation. Probiotic strains and prebiotic were selected for their abilities to restore vaginal ecosystem. Microparticles were produced by emulsification/gelation method using calcium as cross-linking agent.

Gliadin characterization by SANS and gliadin nanoparticle growth modelization.

Nanosized colloidal carriers can ensure a controlled and targeted therapeutic substances delivery. The original contribution of this work was to use biopolymers of vegetable source, which are an interesting alternative to synthetic polymers. The aim of this study was to prepare submicronic particles from wheat proteins: Gliadins extracted from gluten.

Microspheres based on inulin for the controlled release of serine protease inhibitors: preparation, characterization and in vitro release.

The pharmacological activity of serine protease inhibitors, potential drugs for the treatment of thrombosis, is often linked to the presence of amidine functions. With the aim of developing a suitable formulation for these compounds, inulin and inulin acetate associated or not with 1,12-dodecanedicarboxylic acid, were chosen to prepare microspheres. Using a coacervation method, these biocompatible polymers led to microspheres of about 0.

Evaluation of gliadins nanoparticles as drug delivery systems: a study of three different drugs.

In this paper, biopolymer nanoparticles are studied, which unlike many synthetic carriers used for controlled release, are biocompatible and biodegradable systems. Gliadins nanoparticles are obtained by a desolvatation method, also known as drawning-out precipitation. These particles have been shown to be interesting as drug release systems for all-trans-retinoic acid.

Biopolymeric colloidal carriers for encapsulation or controlled release applications.

Biopolymers represent an interesting alternative to synthetic polymers in order to be used as structured carriers for controlled release and encapsulation applications. In particular, the ability of these carriers to entrap both hydrophilic and hydrophobic drugs may be very promising for many applications. In addition, the absence of chemical compounds and organic solvents used to produce biopolymeric matrices could be very interesting for some industrial applications.

[Wheat gliadin nanoparticle size control by determination of the solubility parameters of these plant proteins].

Gliadins nanoparticles, protein complex from wheat gluten, were prepared by coacervation (macromolecules desolvatation). The objective was to prepare nanometric colloidal systems whith both smallest particle size and polidispersity index. Macromolecules solvent choice is predominant.

Alpha-tocopherol encapsulation and in vitro release from wheat gliadin nanoparticles.

Alpha-tocopherol, or vitamin E (VE), is widely used as a strong antioxidant in many medical and cosmetic applications, but is rapidly degraded, because of its light, heat and oxygen sensitivity. Thus, all of its formulation has to avoid contact with light, heat or air. Drug loaded carriers are an attractive opportunity, especially if they are made for bioacceptable macromolecules such as vegetal proteins.

Vesicles and particles of sodium bis(2-ethylhexyl) phosphate in binary and ternary systems.

Vesicles were identified in aqueous solution of pure sodium bis(2-ethylhexyl) phosphate, a short branched chain surfactant. Superficial tension measurements show that the vesicles appear above a molality of 0.02 (0.