Publications by authors named "Najmuddin Mohd Saquib"
We evaluated the potential relevance of our multi-cancer detection test, OncoVeryx-F, for ovarian cancer screening. For this, we compared its accuracy with that of CA125-based screening. We demonstrate here that, in contrast to CA125-based detection, OncoVeryx-F detected ovarian cancer with very high sensitivity and specificity.
View Article and Find Full Text PDFObjective: Signal transduction not only initiates entry into the cell cycle, but also reprograms the cell's metabolism. To control abnormalities in cell proliferation, both the aspects should be taken care of, thus pleiotropic signaling molecules are considered as crucial modulators. Considering this, we investigated the role of AKT1 in central carbon metabolism.
View Article and Find Full Text PDFArticle Synopsis
- The study explores how Mycobacterium tuberculosis (Mtb) alters the endoplasmic reticulum (ER) in macrophages, revealing distinct ER structures for virulent (H37Rv) versus avirulent (H37Ra) strains.
- Using advanced proteomics and lipidomics, researchers found that these changes impact host-pathogen interactions, affecting protein and lipid composition in the ER.
- The findings suggest that H37Ra promotes apoptosis by manipulating calcium levels and lipid expression, while H37Rv inhibits apoptosis and disrupts cholesterol balance to ensure persistent infection.