Publications by authors named "Najla Hfaiedh"

A grapevine shoot extract (GSE) was obtained using ultrasound-assisted extraction and characterized. The main phenolic constituents were identified as stilbenoids. Among them, -resveratrol and -ε-viniferin stood out.

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The aim of the study is to assess the suitability of the herbal formulation for topical application as a skin burn dressing on the in vivo wound-closure of third-degree wound injuries. Rat wound models were used to prove the in vivo skin burn-healing process. Body weight gain, food and water intake, and behavior were investigated daily during treatment period.

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Background: The drumstick tree Lam. (Moringaceae), distributed in many parts of the world, is an important food plant with high nutritional value and used in medical applications and pharmaceutical industries. The aim of this study was to highlight the gastroprotective effect of in hydrochloric acid/Ethanol (HCl/EtOH) in a rat model.

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The aim of the report is to assess the protective effect of powder aerial part of Teucrium ramosissimum (TS) on the in vivo wound-healing of second-degree burn injuries. Teucrium phytocompounds were characterized by FTIR, HPLC, and GC/MS spectra. Burn wound models were employed to evaluate the in vivo wound-healing activity.

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Medicinal plants are sources of natural antioxidants thanks to their secondary metabolites. Previous studies showed that administration of (EG) ( family) was found to alleviate the deleterious effects of obesity-induced damage on liver, heart and kidney. This study, carried out on adult male Wistar rats, evaluates the inhibitory effects of supplementation with extract on obesity.

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In the present work, the effect of seed pre-soaking with gallic acid (GA; 3,4,5-triphydroxyl-benzoic acid) in conferring subsequent tolerance to Cd stress in sunflower (Helianthus annuus) seedlings was investigated. Exposing sunflower seedlings to increasing Cd concentrations (5, 10 and 20 μM) caused a gradual decrease in root and shoot biomass and increased the metal accumulation in both organs. Seed pretreatment with 75 µM GA significantly restricted Cd uptake, markedly alleviated Cd-induced plant growth inhibition, and mitigated the oxidative damages caused by this metal, as compared to plants directly exposed to Cd.

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Background: The aim of this research is to investigate the potential activity of Salvia officinalis and various hair samples responsible for secretion of essential oil. In Tunisia, biological activity of Salvia officinalis is poorly recorded. Salvia leaves contain various types of hairs (glandular and nonglandular).

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Medicinal plants and their secondary metabolites have long been a rich source of biologically active compounds that can prevent many diseases. In this context, we investigated the antioxidant activities of the essential oil of Lavandula officinalis and tested its potency against hepatic and renal toxicity induced by hydrogen peroxide in adult male mice based on measurements of biochemical parameters, oxidative stress, and tissue damage in both organs. We proved a remarkable antioxidant power of this plant (in vitro) by correcting the harmful effects of the prooxidant (in vivo).

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In this paper, water-soluble polysaccharides (named as NRLP) were extracted from leaves. The main structural features of NRLP were determined by High-pressure size exclusion chromatography, Fourier transform infrared and Gas Chromatography/Mass Spectrometry-Electronic Impact analysis. The in vitro and in vivo biological potential of NRLP were evaluated by measuring its antioxidant (•OH and DPPH• scavenging, total antioxidant capacity), anti-α-amylase as well as anti-inflammatory and antinociceptive activities in a mice model.

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Brachychiton populneus is one of the unexploited Tunisian plants, traditionally eaten as food and used for medicinal purposes. The present study aimed to investigate the phytochemical components of the seeds, leaves and flowers from B. populneus using three different solvents and to explore their antioxidant, anti-inflammatory and neuroprotective effects.

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After absorption by the organism, polychlorinated biphenyls (PCBs) cross cellular membranes and pass into blood vessels and the lymphatic system. It is generally in the liver, adipose tissues, brain and skin that we find the strongest concentrations of PCBs. Herbal medicine remains as a discipline intended to treat and to prevent certain functional disorders and/or pathologies caused by oxidative stress, which can be induced by pesticides, medicines or pollutants.

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Article Synopsis
  • - This study investigated the antioxidant properties of "Sahli" leaf extract and its effects on haematotoxicity and nephrotoxicity caused by diclofenac in Swiss albino mice.
  • - Mice were divided into four groups: a control group, a diclofenac-only group, a group given olive leaf extract, and a group that received olive leaf extract before diclofenac treatment.
  • - Results showed that diclofenac alone significantly altered blood parameters and increased oxidative stress, but olive leaf extract successfully restored these parameters and protected kidney tissues from damage.
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The structure, antioxidant and anti-hyperlipidemic activities of polysaccharides from Nitraria retusa fruits (named as NRFP) were investigated. The NRFP fraction, with a molecular weight of 66.5 kDa, was composed of a β-(1 → 3)-glucan, containing neutral sugars (69.

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Objective: This research aimed to evaluate the protective effects of bioactive compounds such as phenolic acids, flavonoids, and tannins present in four species extracted with methanol.

Methods: The total phenolic content of the methanolic extracts was measured spectrophotometrically. The effect of the extracts on cell viability in U266 cells was measured.

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L. (Myrtle) is one of the most important aromatic and medicinal species from the Myrtaceae family. It is traditionally used as antiseptic, disinfectant drug and hypoglycemic agent.

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This study was designed to assess the protective effects of methanol extract (LEM) on liver and kidney injuries induced by cisplatin. The phytochemical composition, the antioxidant activity, and hepatorenal injury biomarkers were investigated. Results revealed that LEM exhibited a significant antioxidant activity on DPPH radical and HO scavenging assays.

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Plants provide an alternative source to manage different human disorders due to various metabolites. The aim of this study is to investigate the phytochemical constituents of the methanolic extracts of and to evaluate their antioxidant, anti-inflammatory, and analgesic activities. The phytochemical results obtained by HPLC and by chemical assay reactions have revealed the richness of the methanolic extract of in active compounds, in particular polyphenols, flavonoids, and tannins.

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Ethnopharmacological Relevance: Lycium europaeum Linn. is widely used to treat the burning of the skin and well-known as a medicinal plant having various biological activities.

Aims Of The Study: The purpose of the present study is to characterize the polysaccharide from L.

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Amaranthus spinosus has been consumed traditionally to prevent various diseases including abdominal pain. In this study, the phytochemical composition, antioxidant and analgesic activities of an ethyl acetate extract of A. spinosus leaves (ASEA) were evaluated.

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In this study, the antioxidant, antinociceptive, hepatoprotective, nephroprotective properties and the bioactive composition of Lycium europaeum were investigated. Polyphenols and total tannin contents were measured by colorimetric methods The antioxidant activity in vitro was evaluated using the reducing power, 2,2-diphenyl-1-picrylhydrazyl radical and phosphomolybdenum assays. The hepatotoxicity and nephrotoxicity effects were studied using carbon tetrachloride (CCl)-induced liver and renal injuries in mice.

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Article Synopsis
  • Alpha-pinene is an important compound from coniferous tree essential oils known for its biological activities, and this study focused on its protective effects against aspirin-induced toxicity in IEC-6 cells.* -
  • The study utilized DPPH and FRAP tests to analyze alpha-pinene's antioxidant activities, finding significant effects on cell viability and oxidative stress indicators like GSH and MDA.* -
  • Results indicated that alpha-pinene enhances cell survival in the presence of aspirin and can block the activation of certain stress pathways, suggesting its potential as a protective agent against oxidative stress.*
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Context: Essential oils from Pinus species have been reported to have various therapeutic properties.

Objective: This study was undertaken to identify the chemical composition and cytoprotective effects of the essential oil of Pinus halepensis L. against aspirin-induced damage in cells in vitro.

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Aspirin, one of the widely used nonsteroidal anti-inflammatory drugs, is the most highly consumed pharmaceutical product in the world. However, it has several side effects in cells. This study was designed to investigate the antioxidative activity and cytoprotective effects of essential oil of Citrus limon (EOC) extracted from leaves against aspirin-induced damages in the rat small intestine epithelial cells (IEC-6).

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Liver and kidney diseases are a global concern, therefore considerable efforts to obtain fine herbs useful as drugs from medicinal plants are currently in progress. The aim of this work was to study the antioxidant effects of previous supplementation with fenugreek seeds (FS) against carbon tetrachloride (CCl) toxicity in the liver and kidney. CCl toxicity was induced by one dose (i.

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