Core proteome mediated subtractive approach for the identification of potential therapeutic drug target against the honeybee pathogen .

Background & Objectives: American foulbrood (AFB), caused by the highly virulent, spore-forming bacterium , poses a significant threat to honey bee brood. The widespread use of antibiotics not only fails to effectively combat the disease but also raises concerns regarding honey safety. The current computational study was attempted to identify a novel therapeutic drug target against , a causative agent of American foulbrood disease in honey bee.

Phenolic Profiling, Antioxidant, and Antibacterial Activities of Selected Medicinal Plants from Tunisia.

Phytochemical screening of aqueous extract from six medicinal wild plants grown in South-eastern of Tunisia: Atriplex halimus, Teucrium polium, Moricandia arvensis, Deverra tortuoa, Haplophyllum tuberculatum and Polygonum equisetiforme were evaluated. Both decoction and ultrasound assisted extraction were used. Antioxidant, antibacterial proprieties, and phenolic profiling, using LC-ESI-MS method, were assessed.

Effects of L. extracts on the proliferation and the differentiation of the acute myeloid leukemia cell line U937.

Epidemiologic studies keep up the proposition that vegetables can lower the risk of cancers. Acute myeloid leukemia (AML) cells exhibit high proliferative potency and have a reduced capacity of undergoing apoptosis and maturation. The beneficial effects of seem related to the organosulfur products generated upon processing of these species.

Biochemical Composition and Biological Activities of Various Population of Growing Wild in Tunisia.

, commonly known (Aslooz) in Tunisia, is an annual plant, native to the North Africa and Middle East. species are used as food, their young leaves can be cooked, providing nutrients and health-giving phytochemicals such as phenolic compounds, polyphenols and carotenoids. Phytochemical composition and bioactivity of leaf extracts, collected from four different bioclimatic zones in Tunisia, are investigated in the present study.

Seasonal changes in rosemary species: A chemotaxonomic assessment of two varieties based on essential oil compounds, antioxidant and antibacterial activities.

Rosemary (Rosmarinus officinalis L.) is a popular herb in cooking, traditional healing, and aromatherapy. This study was conducted to evaluate the effects of meteorological conditions plant growth stage and genetic factors on the yield, quantitative and qualitative composition, on the antioxidant and antimicrobial activities of rosemary essential oil from two Tunisian locations (El Fahs and Matmata) during two successive years.

The polyphenol/saponin-rich Rhus tripartita extract has an apoptotic effect on THP-1 cells through the PI3K/AKT/mTOR signaling pathway.

Background: Hyperactivation of mechanistic target of rapamycin (mTOR) signaling pathway is involved in the regulation of cellular growth, proliferation, and more in general, is a common phenomenon in most types of cancers. Thus, natural substances targeting this pathway can be of great therapeutic potential in supporting the treatment of tumor patients. Rhus tripartita (Ucria) Grande is a plant growing in desertic areas which is traditionally used for the treatment of several diseases in Tunisia.

Allium roseum L. extract inhibits amyloid beta aggregation and toxicity involved in Alzheimer's disease.

Allium roseum is an important medicinal and aromatic plant, specific to the North African flora and a rich source of important nutrients and bioactive molecules including flavonoids and organosulfur compounds whose biological activities and pharmacological properties are well known. In the present study, the inhibition of amyloid beta protein toxicity by the ethanolic extract of this plant is investigated for the first time. Preliminary biochemical analyses identified kæmpferol and luteolin-7-o-glucoside as the more abundant phenolic compounds.

Freeze-dried, oven-dried, and microencapsulation of essential oil from as potential preservative agents of minced meat.

The present study was conducted to compare the antibacterial activity of oven-dried and freeze-dried along with its spray-dried microencapsulated essential oil in the preservation of minced beef meat. extracts were tested against mesophilic aerobic microorganisms, coagulase-positive , , sp., and the sulfite-reducing anaerobes.

Biochemical profile and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia.

Recently, much attention has been paid to the extracts obtained from plant species in order to analyse their biological activities. Due to the climate diversity in Tunisia, the traditional pharmacopoeia consists of a wide arsenal of medicinal plant species since long used in folk medicine, in foods as spices, and in aromatherapy. Although many of these species are nearly facing extinction, only a small proportion of them have been scientifically studied.

Polyphenolic profile, antibacterial activity and brine shrimp toxicity of leaf extracts from six Tunisian spontaneous species.

The aim of this study was to investigate the polyphenolic profile and biological properties of leaves acetonic extracts from six Tunisian spontaneous plants of L., (Ucria) D.C.

Allium Roseum L. Extract Exerts Potent Suppressive Activities on Chronic Myeloid Leukemia K562 Cell Viability Through the Inhibition of BCR-ABL, PI3K/Akt, and ERK Pathways and the Abrogation of VEGF Secretion.

Use of plant extracts, alone or combined to the current chemotherapy as chemosensitizers, has emerged as a promising strategy to overcome tumor drug resistance. Here, we investigated the anticancer activity of Allium roseum L. extracts, a wild edible species in North Africa, on human Chronic Myeloid Leukemia (CML) K562 cells.

Anti-inflammatory and anti-proliferative activities of the wild edible cruciferous: Diplotaxis simplex.

Context The present study deals with new biological properties of the wild edible Diplotaxis simplex (Viv.) Spreng (Brassicaceae). Objectives The current study evaluates the antioxidant, the anti-inflammatory and the anti-cancer properties of ethyl acetate and ethanol extracts from D.

Thin layer convective air drying of wild edible plant (Allium roseum) leaves: experimental kinetics, modeling and quality.

The present study deals with the valorization of an edible spontaneous plant of the Tunisian arid areas: Allium roseum. This plant is traditionally used for therapeutic and culinary uses. Thin-layer drying behavior of Allium roseum leaves was investigated at 40, 50 and 60 °C drying air temperatures and 1 and l.

Arthrophytum scoparium inhibits melanogenesis through the down-regulation of tyrosinase and melanogenic gene expressions in B16 melanoma cells.

Melanin performs a crucial role in protecting the skin against harmful ultraviolet light. However, hyperpigmentation may lead to aesthetic problems and disorders such as solar lentigines (SL), melasma, postinflammatory hyperpigmentation and even melanoma. Arthrophytum scoparium grows in the desert in the North African region, and given this type of environment, A.

Biological and chemical study of Astragalus gombiformis.

Extracts of aerial parts and roots of wild Astragalus gombiformis Pomel were tested for their antibacterial, antioxidant, and insecticidal activities and contents of phenolic compounds. Antibacterial activity was tested by the paper disk agar diffusion method and determination of the minimal inhibitor concentration. Among the tested extracts, three extracts (methanol, chloroform, and ethyl acetate) from aerial parts and two extracts (water, methanol) from roots exhibited diameters of inhibition zone equal or above 12 mm (at 150 microg/ disk) and minimal inhibitor concentrations ranging between 233 and 1250 microg/ml.