Tonometric devices for central aortic systolic pressure measurements in patients with type 1 diabetes: comparison of the BPro and SphygmoCor devices.

Objective: Central blood pressure may be a better risk marker than brachial blood pressure and can be measured noninvasively by tonometric devices. We investigate whether tonometric measurements are feasible in patients with diabetes and whether the degree of albuminuria or increased arterial stiffness affects measurements.

Patients And Methods: In 676 patients with type 1 diabetes, comparison of central aortic systolic pressure (CASP) measurements by the BPro and the SphygmoCor devices were made.

Microbial biomass in faeces of dairy cows affected by a nitrogen deficient diet.

Since more than half of the faecal nitrogen (N) originates from microbial N, the objective of the study was to develop a method for quantitatively detecting microbial biomass and portion of living microorganisms in dairy cattle faeces, including bacteria, fungi and archaea. Three techniques were tested: (1) the chloroform fumigation extraction (CFE) method, (2) detection of the fungal cell-membrane component ergosterol and (3) analysis of the cell wall components fungal glucosamine and bacterial muramic acid. In a second step, an N deficient (ND) and an N balanced (NB) diets were compared with respect to the impacts on faecal C and N fractions, microbial indices and digestibility.

Pre-existing anti-adeno-associated virus antibodies as a challenge in AAV gene therapy.

Adeno-associated virus (AAV)-based vectors are promising tools for gene therapeutic applications, in part because AAVs are nonpathogenic viruses, and vectors derived from them can drive long-term transgene expression without integration of the vector DNA into the host genome. AAVs are not strongly immunogenic, but they can, nonetheless, give rise to both a cellular and humoral immune response. As a result, a significant fraction of potential patients for AAV-based gene therapy harbors pre-existing antibodies against AAV.

Measurement of Z boson production in Pb-Pb collisions at sqrt[s(NN)]=2.76 TeV with the ATLAS detector.

The ATLAS experiment has observed 1995 Z boson candidates in data corresponding to 0.15  nb(-1) of integrated luminosity obtained in the 2011 LHC Pb+Pb run at sqrt[s(NN)]=2.76  TeV.

Search for dark matter candidates and large extra dimensions in events with a photon and missing transverse momentum in pp collision data at sqrt[s]=7 TeV with the ATLAS detector.

Results of a search for new phenomena in events with an energetic photon and large missing transverse momentum in proton-proton collisions at sqrt[s] = 7 TeV are reported. Data collected by the ATLAS experiment at the LHC corresponding to an integrated luminosity of 4.6 fb(-1) are used.

Search for magnetic monopoles in sqrt[s]=7 TeV pp collisions with the ATLAS detector.

This Letter presents a search for magnetic monopoles with the ATLAS detector at the CERN Large Hadron Collider using an integrated luminosity of 2.0  fb(-1) of pp collisions recorded at a center-of-mass energy of sqrt[s]=7  TeV. No event is found in the signal region, leading to an upper limit on the production cross section at 95% confidence level of 1.

Improved luminosity determination in collisions at [Formula: see text] using the ATLAS detector at the LHC.

The luminosity calibration for the ATLAS detector at the LHC during collisions at [Formula: see text] in 2010 and 2011 is presented. Evaluation of the luminosity scale is performed using several luminosity-sensitive detectors, and comparisons are made of the long-term stability and accuracy of this calibration applied to the collisions at [Formula: see text]. A luminosity uncertainty of [Formula: see text] is obtained for the 47 pb of data delivered to ATLAS in 2010, and an uncertainty of [Formula: see text] is obtained for the 5.

Search for a light charged Higgs boson in the decay channel [Formula: see text] in [Formula: see text] events using collisions at [Formula: see text] with the ATLAS detector.

A search for a charged Higgs boson () in [Formula: see text] decays is presented, where one of the top quarks decays via →, followed by → two jets ([Formula: see text]). The other top quark decays to , where the  boson then decays into a lepton (/) and a neutrino. The data were recorded in collisions at [Formula: see text] by the ATLAS detector at the LHC in 2011, and correspond to an integrated luminosity of 4.

Measurement of splitting scales in → events at [Formula: see text] with the ATLAS detector.

A measurement of splitting scales, as defined by the clustering algorithm, is presented for final states containing a boson produced in proton-proton collisions at a centre-of-mass energy of 7 TeV. The measurement is based on the full 2010 data sample corresponding to an integrated luminosity of 36 pb which was collected using the ATLAS detector at the CERN Large Hadron Collider. Cluster splitting scales are measured in events containing bosons decaying to electrons or muons.

Multi-channel search for squarks and gluinos in [Formula: see text] collisions with the ATLAS detector at the LHC.

A search for supersymmetric particles in final states with zero, one, and two leptons, with and without jets identified as originating from -quarks, in 4.7 fb of [Formula: see text] collisions produced by the Large Hadron Collider and recorded by the ATLAS detector is presented. The search uses a set of variables carrying information on the event kinematics transverse and parallel to the beam line that are sensitive to several topologies expected in supersymmetry.

Measurement of the [Formula: see text] production cross section in the tau + jets channel using the ATLAS detector.

A measurement of the top quark pair production cross section in the final state with a hadronically decaying tau lepton and jets is presented. The analysis is based on proton-proton collision data recorded by the ATLAS experiment at the LHC, with a centre-of-mass energy of 7 TeV. The data sample corresponds to an integrated luminosity of 1.

Jet energy resolution in proton-proton collisions at [Formula: see text] recorded in 2010 with the ATLAS detector.

The measurement of the jet energy resolution is presented using data recorded with the ATLAS detector in proton-proton collisions at [Formula: see text]. The sample corresponds to an integrated luminosity of 35 pb. Jets are reconstructed from energy deposits measured by the calorimeters and calibrated using different jet calibration schemes.

Measurement of jet shapes in top-quark pair events at [Formula: see text] using the ATLAS detector.

A measurement of jet shapes in top-quark pair events using 1.8 fb of [Formula: see text] collision data recorded by the ATLAS detector at the LHC is presented. Samples of top-quark pair events are selected in both the single-lepton and dilepton final states.

Search for direct top squark pair production in final states with one isolated lepton, jets, and missing transverse momentum in sqrt[s] = 7 TeV pp collisions using 4.7 fb(-10 of ATLAS data.

A search is presented for direct top squark pair production in final states with one isolated electron or muon, jets, and missing transverse momentum in proton-proton collisions at sqrt[s] = 7 TeV. The measurement is based on 4.7 fb(-1) of data collected with the ATLAS detector at the LHC.

Search for a supersymmetric partner to the top quark in final states with jets and missing transverse momentum at sqrt[s] = 7 TeV with the ATLAS detector.

A search for direct pair production of supersymmetric top squarks (t(1)) is presented, assuming the t(1) decays into a top quark and the lightest supersymmetric particle, χ(1)(0), and that both top quarks decay to purely hadronic final states. A total of 16 (4) events are observed compared to a predicted standard model background of 13.5(-3.

Arterial stiffness is associated with cardiovascular, renal, retinal, and autonomic disease in type 1 diabetes.

Objective: In patients with type 1 diabetes, we investigated the association between arterial stiffness and diabetes complications.

Research Design And Methods: This was a cross-sectional study including 676 Caucasian patients with type 1 diabetes (374 [55%] men, aged 54 ± 13 years [mean ± SD]) and 51 nondiabetic controls (28 [55%] men, aged 47 ± 13 years). Aortic pulse wave velocity (PWV) was measured with SphygmoCor (AtCor Medical, Sydney, Australia) for 635 patients and all 51 controls.

Pregestational body mass index is related to neonatal abdominal circumference at birth--a Danish population-based study.

Objectives: To examine the impact of maternal pregestational body mass index (BMI) and smoking on neonatal abdominal circumference (AC) and weight at birth. To define reference curves for birth AC and weight in offspring of healthy, nonsmoking, normal weight women.

Design: Population-based study.

Analysis of single-cell gene transcription by RNA fluorescent in situ hybridization (FISH).

Adhesion of Plasmodium falciparum infected erythrocytes (IE) to human endothelial receptors during malaria infections is mediated by expression of PfEMP1 protein variants encoded by the var genes. The haploid P. falciparum genome harbors approximately 60 different var genes of which only one has been believed to be transcribed per cell at a time during the blood stage of the infection.

Discrepancy between tonometric ambulatory and cuff-based office blood pressure measurements in patients with type 1 diabetes.

The aim of the current study was to compare ambulatory blood pressure (ABP) with office blood pressure (OBP) in diagnosing hypertension (HTN) in type 1 diabetes. The cross-sectional study included 569 type 1 diabetes patients, with a mean ± standard deviation (SD) age of 55 ± 13 years and diabetes duration of 33 ± 16 years, and 315 (55%) men. Blood pressure ≥ 130/80 mm Hg defined HTN.

Determination of the strange-quark density of the proton from ATLAS measurements of the W→ℓν and Z→ℓℓ cross sections.

A QCD analysis is reported of ATLAS data on inclusive W(±) and Z boson production in pp collisions at the LHC, jointly with ep deep-inelastic scattering data from HERA. The ATLAS data exhibit sensitivity to the light quark sea composition and magnitude at Bjorken x∼0.01.

The prognostic importance of miR-21 in stage II colon cancer: a population-based study.

Background: Despite several years of research and attempts to develop prognostic models a considerable fraction of stage II colon cancer patients will experience relapse within few years from their operation. The aim of the present study was to investigate the prognostic importance of miRNA-21 (miR-21), quantified by in situ hybridisation, in a unique, large population-based cohort.

Patients And Methods: The study included 764 patients diagnosed with stage II colon cancer in Denmark in the year 2003.

Search for pair production of a new b' quark that decays into a Z boson and a bottom quark with the ATLAS detector.

A search is reported for the pair production of a new quark b' with at least one b' decaying to a Z boson and a bottom quark. The data, corresponding to 2.0 fb(-1) of integrated luminosity, were collected from pp collisions at √s = 7 TeV with the ATLAS detector at the CERN Large Hadron Collider.