Esophageal polypoidal mass: presentation of an uncommon pleomorphic carcinoma.

Pleomorphic carcinomas are primary malignant tumours that are known to arise in the lungs, pancreas, gall bladder and intestine. A patient with polypoid tumour of the esophagus is described in this report. The patient presented with dysphagia.

Rhinosporidiosis presenting as an urethral polyp.

Rhinosporidiosis is an inflammatory disease caused by Rhinosporidium seeberi, a protoctistan mesomycetozoa, member of a group of novel aquatic parasites, characterized by hyperplastic polypoid lesions of the nasal cavity and rarely other mucous membranes. We report an unusual presentation of rhinosporidiosis as an urethral polyp, which is only the second case of rhinosporidiosis reported from Pakistan.

Frequency of primary solid malignant neoplasms in different age groups as seen in our practice.

Background: To determine in a large series of surgical biopsies, the frequency of various histologic types of primary solid malignant neoplasms in males and females in different age groups.

Methods: A retrospective study of 20,000 consecutive surgical biopsies reposted in the section of histopathology, AKU in 2004.

Results: Malignant neoplasms are commonest in the fifth and sixth decades of life.

Thymoma : a clinicopathologic association of world health organization histologic subtype and invasive behaviour.

Objective: To re-classify thymic epithelial neoplasms reported at Aga Khan University Hospital during the past seven years according to the revised WHO classification, to assess the ease of application and determine association between WHO histological subtype and invasive behaviour.

Design: Descriptive study.

Place And Duration Of Study: The study was carried out in the section of Histopathology, Department of Pathology and Microbiology, Aga Khan University Hospital, Karachi, from January 2000 to October 2006.

Gastric carcinoma: typing, staging, lymph node and resection margin status on gastrectomy specimens.

Objective: To determine the extent and stage of gastric carcinoma on gastrectomy specimens in terms of type, grade, location, depth of invasion, resection margins and lymph node status.

Study Design: Descriptive study.

Place And Duration Of Study: Section of Histopathology, Department of Pathology, Aga Khan University, Karachi during 2005 and 2006.

Frequency of primary solid malignant neoplasms in both sexes, as seen in our practice.

Background: To determine the frequency of various histologic types of primary solid malignant neoplasms in males and females, in our practice, in a large series of surgical biopsies.

Methods: A retrospective study of 20,000 consecutive surgical biopsies in the section of Histopathology, Aga Khan University Hospital (AKU), Karachi, in 2004.

Results: Squamous cell carcinoma of oral cavity was the commonest malignant neoplasm in males followed by diffuse Large B cell, Non-Hodgkin's lymphoma and Prostatic adenocarcinoma.

Unusual metastases of hepatocellular carcinoma (hcc) to bone and soft tissues of lower limb.

Hepatocellular carcinoma metastasizing to bones and soft tissues of extremities is an unusual occurrence. The present report describes two such cases, where this unusual happening was the presenting feature. Role of immunohistochemistry for diagnosis is emphasized.

Subependymal giant cell astrocytoma.

Subependymal giant cell astrocytomas (SEGAs) are slowly growing tumours corresponding to WHO grade I. They are intraventricular and usually occur in the setting of tuberous sclerosis complex. They often result in obstructive hydrocephalus.

Significance of immunohistochemistry in accurate characterization of malignant tumors.

Background: To determine in a large series of surgical biopsies the role and significance of immunohistochemistry in the adequate and accurate characterization of malignant tumors.

Methods: A retrospective study of 20,000 consecutive surgical biopsies reported in the Section of Histopathology, AKU in 2003. Data was obtained by retrieving the filed surgical biopsy reports in the section.

Uterine perivascular epithelioid cell tumour presenting as a cervical mass.

Perivascular Epithelioid Cell Tumour (PEComa) also known as myelomelanocytic tumours are uncommon, recently described mesenchymal tumours that include angiomyolipoma, clear cell "sugar" tumour of the lung, lymphangioleiomyoma and tumours composed predominantly of epithelioid cell morphology. A predilection for uterus has been described. However up till now only 14 cases of uterine PEComas have been described.

Cns tumors at AKU: an update plus a brief discussion on intraventricular tumors with special emphasis on central neurocytoma.

Background: This paper is intended to be an update of our earlier published work on CNS tumors along with additional information on intraventricular tumors. Three cases of central neurocytoma are also discussed.

Methods: An analysis conducted in the Section of Histopathology, AKU to determine the frequency of all CNS neoplasms diagnosed between Jan 1, 1994 and Dec 31, 2001.

Demographic and Clinicopathologic features of membranous glomerulonephritis.

Objective: To determine the frequency of membranous glomerulonephritis(MGN) in the renal biopsy specimens. To observe the presenting features and the demographics to determine association, if any, between MGN and hepatitis B in these patients.

Design: Descriptive study.