Renal Allograft Biopsy Findings in Live-related Renal Transplant Recipients.

Objective:  To determine the pattern of histopathology in living-related, kidney transplant recipients (KTRs) from a transplant centre in Khyber Pakhtunkhwa (KPK), Pakistan.

Study Design: Descriptive, observational study.

Place And Duration Of Study: Institute of Kidney Diseases, Peshawar, from August 2008 to July 2018.

Haemobilia: secondary to micro aneurysms of hepatic artery.

Hepatic artery is the fourth most common site of the intraabdominal aneurysm, after infra renal aorta, iliac artery and splenic artery aneurysms. Rupture of the aneurysm may lead to the upper gastrointestinal haemorrhage. Here we report a 5 years old boy, who presented with fever, abdominal distension and unexplained upper GI bleed.

Crizotinib in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma in the setting of renal insufficiency: a case report.

Background: In vitro studies confirmed cytoreductive anti-tumor activity of crizotinib in experimental models of anaplastic large cell lymphoma in 2007. One case series and a few case reports describe the use of crizotinib in relapsed or refractory anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Even though data are limited regarding the dose of crizotinib in renal insufficiency, our case was successfully treated with a lower dose of crizotinib.

Management of Lung Cancer in the Elderly.

Lung cancer disproportionately affects the elderly. Aging is typically associated with higher risk of comorbidity, declines in physical, organ, and cognitive function, and diminished social support. Hence the management of a disease as complex and potentially lethal as lung cancer in this population is challenging.

Diagnostic utility of endoscopic ultrasound guided aspiration cytology in evaluation of pancreatic masses.

Objective: To determine the sensitivity and specificity of endoscopic ultrasound (EUS) guided fine needle aspiration cytology (FNAC) in the evaluation of pancreatic masses.

Study Design: Analytical study.

Place And Duration Of Study: Department of Pathology, Shaukat Khanum Cancer Hospital and Research Centre, from January 2006 to June 2011.

Clinical presentations of nephrotic syndrome in patients of a tertiary care hospital at Peshawar.

Background: Nephrotic syndrome (NS) is manifested by presence of pitting oedema, profound proteinuria in excess of 3.5 g/day, serum albumin levels of less than 3.0 g/dL and hypercholesterolemia.

Bleomycin induced pulmonary toxicity in patients with germ cell tumours.

Background: Bleomycin is a cytotoxic drug used in treatment of Germ Cell Tumours (GCTs) and is associated with pulmonary toxicity. Bleomycin pulmonary toxicity (BPT) manifests predominantly as pulmonary fibrosis, organising pneumonia (OP) or Nonspecific Interstitial Pneumonitis (NSIP). Our objectives were to determine the incidence of BPT, describe the common HRCT patterns of pulmonary toxicity and to find out the correlation of variables (cumulative dose of bleomycin, age and glomerular filtration rate) with pulmonary toxicity.

Targeting lymphotoxin beta receptor with tumor-specific T lymphocytes for tumor regression.

Purpose: One of the impediments of immunotherapy against cancer is the suppression of tumor-specific CTLs in the tumor microenvironment, partly due to the selective inhibition of the perforin pathway and the emergence of Fas-resistant tumors. Therefore, we sought to identify perforin- and Fas-independent cytotoxic pathways and explored the potential of targeting LTbetaR with tumor-specific CTLs to induce tumor rejection in vivo.

Experimental Design: Fas-resistant tumors were examined for their susceptibility to perforin-deficient (pfp) CTLs via CTL adoptive transfer in mouse models of experimental lung metastasis.