This study focused on loading the natural drug phycion (PHY) into metal-organic frameworks (MOFs), specifically zeolitic imidazolate frameworks (ZIFs), using a simple nano-precipitation technique.
The resulting PHY@ZIF-8 showed a high drug loading efficiency of 88% and a capacity of 11.49%, with effective characterization performed using various analytical methods.
Importantly, PHY@ZIF-8 demonstrated significantly improved drug release at lower pH levels and exhibited better antibacterial activity than pure PHY, suggesting its potential for treating infectious diseases.