Protein-ligand interaction prediction based on heterogeneity maps and data enhancement.

Prediction of protein-ligand interactions is critical for drug discovery and repositioning. Traditional prediction methods are computationally intensive and limited in modeling structural changes. In contrast, data-driven deep learning methods significantly reduce computational costs and offer a more efficient approach for drug discovery.

Position-dependent resource competition within inflorescences of Sagittaria trifolia.

Resource competition among flowers is expected to influence variation in seed output within inflorescences, but the extent to which flower position affects competitive interactions is still incompletely understood. To investigate position effects on seed output in the perennial, monoecious macrophyte Sagittaria trifolia, we compared components of seed production (fruit set, seed number per fruit, and seed size) in control inflorescences to that in inflorescences from which half of the female flowers were experimentally removed, either from basal positions, from upper positions, or from across the inflorescence. Basal and upper flower removal reduced total seed output per inflorescence, while the throughout removal treatment maintained a seed yield comparable to the control.

Magnetically targeted delivery of probiotics for controlled residence and accumulation in the intestine.

The effectiveness of orally delivered probiotics in treating gastrointestinal diseases is restricted by inadequate gut retention. In this study, we present a magnetically controlled strategy for probiotic delivery, which enables controlled accumulation and residence of probiotics in the intestine. The magnetically controlled probiotic is established by attaching amino-modified iron oxide (FeO-NH NPs) to polydopamine-coated GG (LGG@P) through electrostatic self-assembly and named as LGG@P@FeO.

A Novel Model for Cornea Power Shift in Eyes Wearing Orthokeratology Lenses With Different Back Optic Zone Diameters for Myopia Control.

Purpose: The purpose of this study was to quantify the corneal power changes after wearing orthokeratology lenses of different back optic zone diameters (BOZDs) and to propose a novel 4-parameter model capable of revealing the associations between each parameter and axial length growth (ALG).

Methods: A prospective self-controlled study was conducted between June 2022 and December 2023. One eye in each subject (N = 33) was randomly assigned to wear a lens with a BOZD of either 5 mm (5 oz) or 6 mm (6 oz).

Outcomes of Older Adults With Delirium Discharged From the Emergency Department.

Study Objective: To compare 30-day mortality and return emergency department (ED) visits among older adults with delirium who are discharged home with those discharged home without delirium and those who are admitted to the hospital with and without delirium.

Methods: Adults aged 75 and older years were assessed for delirium using the Delirium Triage Screen followed by the Brief Confusion Assessment Method. We evaluated outcomes including return visits and 30-day mortality.

New Insight into the Mechanism of Neurochemical Imbalance in Multiple Sclerosis: Abnormal Transportation of Brain Extracellular Space.

Neurochemical imbalance is a contributing factor to neurological symptoms in multiple sclerosis (MS). The matured myelin sheath is crucial for substance transportation within the extracellular space (ECS) and for maintaining local homeostasis. Therefore, we hypothesize that disturbed ECS transportation following demyelinating lesions might lead to neurochemical imbalance in MS.

A method of reference phase velocity selecting for bearing estimation with a horizontal line array in shallow water.

In shallow water environments, choosing an appropriate reference phase velocity for direction-of-arrival estimation with a beamformed underwater horizontal line array is very important. The direction of the maximum beamformer output power will deviate from the true source bearing when a mismatched reference phase velocity was used. This Letter analyzed the intrinsic relationship between the reference phase velocity and normal mode amplitude distribution, source bearing, array aperture, and then proposed a multi-parameter weighted reference phase velocity selection method, which has improved the accuracy of source bearing estimation.

A new pyrrolopyrazine alkaloid from the fruit of .

A new pyrrolopyrazine alkaloid, named lycipyrazine A (), alone with seven known alkaloids (-), were isolated from the fruit of The structure of new compound was determined using extensive 1D and 2D spectroscopic analyses, while its absolute configuration was determined by comparison of its experimental and calculated ECD spectra. Their -glucosidase inhibitory activity was screened using acarbose as a positive control. Compound showed strong inhibitory activity against -glucosidase (IC = 3.

Effects of faecal microbiota transplantation supplemented with inulin on early immunity and immune organ histomorphology in chickens.

1. Faecal microbiota transplantation (FMT) is a technique that promotes gut microbiota diversity and abundance by transplantation of faeces into a recipient's gastrointestinal tract multiple routes.2.

Boosted Scavenger-Free Overall Nitrogen Photofixation with Molybdenum Incorporated Bismuth-Rich Oxychlorides.

The design of highly efficient photocatalysts to photoreduce nitrogen (N) to ammonia (NH) under mild conditions is extremely challenging. In this work, various molar ratio of molybdenum (Mo) is incorporated into BiOCl via a hydrothermal process. The resulting Mo-doped BiOCl exhibits remarkable solar-driven activity for N photo fixation without any scavengers or sacrificial agents.

MoSe/BiSe Heterostructure Immobilized in N-Doped Carbon Nanosheets Assembled Flower-Like Microspheres for High-Rate Sodium Storage.

A key challenge for sodium-ion batteries (SIBs) lies in identifying suitable host materials capable of accommodating large Na ions while addressing sluggish chemical kinetics. The unique interfacial effects of heterogeneous structures have emerged as a critical factor in accelerating charge transfer and enhancing reaction kinetics. Herein, MoSe/BiSe composites integrated with N-doped carbon nanosheets are synthesized, which spontaneously self-assemble into flower-like microspheres (MoSe/BiSe@N-C).

Enhanced Hot/Free Electron Effect for Photocatalytic Hydrogen Evolution Based on 3D/2D Graphene/MXene Composite.

Photocatalytic hydrogen production through water splitting represents a promising strategy to store solar energy as chemical energy. Current photocatalysts primarily focus on traditional semiconductor materials, such as metal oxides, sulfides, nitrides, g-CN, etc. However, these materials often suffer from large bandgap and fast charge recombination, which limit sunlight utilization and result in unsatisfactory photon conversion efficiency.

Bio-Inspired Retina by Regulating Ion-Confined Transport in Hydrogels.

The effective and precise processing of visual information by the human eye primarily relies on the diverse contrasting functions achieved through synaptic regulation of ion transport in the retina. Developing a bio-inspired retina that uses ions as information carriers can more accurately replicate retina's natural signal processing capabilities, enabling high-performance machine vision. Herein, an ion-confined transport strategy is proposed to construct a bio-inspired retina by developing artificial synapses with inhibitory and excitatory contrasting functions.

A General Strategy for Exceptionally Robust Conducting Polymer-Based Bioelectrodes with Multimodal Capabilities Through Decoupled Charge Transport Mechanisms.

Bioelectrodes function as a critical interface for signal transduction between living organisms and electronics. Conducting polymers (CPs), particularly poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate), are among the most promising materials for bioelectrodes, due to their electrical performance, high compactness, and ease of processing, but often suffer from degradation or de-doping even in some common environments (e.g.

Negative Enthalpy Doping Stabilizes P2-Type Oxides Cathode for High-Performance Sodium-Ion Batteries.

P2-type NaNiMnO (NNMO) as cathode material for sodium-ion batteries (SIBs) largely suffers from continuous accumulation of local stress caused by destructive structural evolution and irreversible oxygen loss upon cycling, leading to rapid capacity degradation. Herein, a strategy of negative enthalpy doping (NED), wherein transition metal (TM) sites are substituted with 0.01 mol each Sn, Sb, Cu, Ti, Mg, and Zn to increase the stability of the TM layers, is proposed.

Investigating the role of eight SNPs in for COPD susceptibility in the Chinese elderly population.

Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality among the elderly in China. Genetic predisposition is a recognized risk factor for COPD, with emerging as a promising candidate gene due to its involvement in smoking behavior and lung function. This study aimed to investigate the association between eight SNPs and COPD susceptibility in the Chinese elderly population.

Volumetric, Microfluidic Plasmonic RT-PCR.

Decentralized molecular detection of pathogens remains an important goal for public health. Although polymerase chain reaction (PCR) remains the gold-standard molecular detection method, thermocycling using Peltier heaters presents challenges in decentralized settings. Recent work has demonstrated plasmonic PCR, where nanomaterials on a surface or nanoparticles in solution heat upon stimulation by light, as a promising method for rapid thermocycling.

Exploring the Dual Nature of Integrated Crop-Livestock Systems: A Review of Environmental Benefits and Risk Challenges.

Integrated crop-livestock systems (ICLS) are acknowledged as both productive and environmentally sustainable, with notable potential to optimize resource use, enhance ecosystem services, and boost crop yields. However, manure application, a critical component of ICLS, may amplify negative environmental impacts, particularly the risks associated with emerging pollutants, which remain underexplored and insufficiently understood. This comprehensive review seeks to thoroughly evaluate the environmental benefits of ICLS.

Enhancing Immune Responses through Modulation of Innate Cell Microenvironments in Lymph Nodes with Virus-Mimetic Vaccines.

Nanovaccines hold significant promise for the prevention and treatment of infectious diseases. However, the efficacy of many nanovaccines is often limited by inadequate stimulation of both innate and adaptive immune responses. Herein, we explore a rational vaccine strategy aimed at modulating innate cell microenvironments within lymph nodes (LNs) to enhance the generation of effective immune responses.

A Bivalent Iridium(III) Complex Toolkit for Mitochondrial DNA G-Quadruplex-Targeted Theranostics.

The G-quadruplex (G4) is an important diagnostic and therapeutic target in cancers, but the development of theranostic probes for subcellular G4s remains challenging. In this work, we report three G4-targeted theranostic probes by conjugating a pyridostatin-derived G4 ligand to G4-specific iridium(III) complexes with desirable photophysical properties. These probes showed specifically enhanced luminescence to mitochondrial G4 in triple negative breast cancer (TNBC) cells.

Attachment styles and attachment (in)security priming in relation to emotional conflict control.

The functional neuro-anatomical model of attachment (NAMA) proposes that the balance between affective evaluation and cognitive control systems can be modulated by adult attachment styles and attachment priming. However, little is known about the characteristics of emotional conflict control that are modulated by attachment patterns. Accordingly, the present study adopted two experiments to investigate the associations between attachment styles, attachment (in)security priming, and emotional conflict control.

A Z-Scheme Heterojunction g-CN/WO for Efficient Photodegradation of Tetracycline Hydrochloride and Rhodamine B.

The construction of heterojunctions can effectively inhibit the rapid recombination of photogenerated electrons and holes in photocatalysts and offers great potential for pollutant degradation. In this study, a Z-scheme heterojunction g-CN/WO photocatalyst was synthesized using a combination of hydrothermal and calcination methods. The photocatalytic degradation performance was tested under visible light; the degradation efficiency of Rh B reached 97.