Publications by authors named "Naixue Wang"
Few prognostic biomarkers exist for lung squamous cell carcinoma (LUSC), which has a poor five-year survival rate. Using bioinformatics, this study evaluated NPLOC4 as a prognostic marker for patients with lung squamous cell carcinoma. Shorter survival periods and tumor growth were linked to high NPLOC4 expression.
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- GREM1 is a secreted protein that plays a role in important biological processes such as embryonic development and tissue differentiation, and it also antagonizes proteins involved in bone and blood vessel development.
- In cancer, GREM1's effects are complex; it can promote tumor growth in some cancers like breast and colon cancer while inhibiting metastasis in pancreatic cancer.
- The review highlights the need for further research on GREM1’s role in tumors, suggesting it could serve as a diagnostic and prognostic marker, with single-cell sequencing technology being a promising avenue for future studies.
Disulfiram (DSF) is an anti-alcoholism medication with superior antitumor activity and clinical safety; its antitumor mechanisms in gastric cancer (GC) have not been fully explored. In the present work, low nontoxic concentrations of copper (Cu) ions substantially enhanced DSF's antitumor activity, inhibiting the proliferation and growth of GC cell lines. DSF/Cu elevated the generation of reactive oxygen species (ROS), and apoptosis was induced in an ROS-dependent manner.
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