Publications by authors named "Naira ElAshmouny"
Biofabricated zinc oxide nanoparticles mitigate acrylamide-induced immune toxicity and modulate immune-related genes and microRNA in rats.
Naunyn Schmiedebergs Arch Pharmacol
November 2024
This study evaluated the potential efficacy of eco-friendly biofabricated zinc oxide nanoparticles (GS-ZnONP) (10 mg/kg b.wt) to reduce the impacts of long-term oral acrylamide (ALD) exposure (20 mg/kg b.wt) on the blood cells, immune components, splenic oxidative status, and expression of CD20, CD3, CD4, CD8, TNF-α, caspase-3, microRNA-181a-5p, and microRNA-125-5p in rats in a 60-day experiment.
View Article and Find Full Text PDFObjective: To evaluate the potential contribution of glycyrrhizin (GLZ) to mitigate the testicular toxicity linked to cisplatin (CIS) intoxication.
Methods: 40 mature male Wistar albino rats (Rattus norvegicus albinus) were randomly divided into 4 equal groups (n = 10) for 60 days: the control group, CIS-treated group (single dose of 7 mg/kg, IP), GLZ-treated group (25 mg/kg, PO), and GLZ plus CIS-treated group. Blood and testis samples were examined using biochemical, histological, and immunohistochemical techniques.
Alleviative effects of green-fabricated zinc oxide nanoparticles on acrylamide-induced oxidative and inflammatory reactions in the rat stomach via modulating gastric neuroactive substances and the MiR-27a-5p/ROS/NF-κB axis.
Tissue Cell
December 2024
Little is known about the effects of acrylamide (AMD) on the stomach. So, this study evaluated the effect of oral AMD exposure (20 mg/kg b.wt) on oxidative status, apoptotic, and inflammatory reactions in rat's stomach for 60 days.
View Article and Find Full Text PDFOkra [ (L.) Moench] improved blood glucose and restored histopathological alterations in splenic tissues in a rat model with streptozotocin-induced type 1 diabetes through CD8 T cells and NF-kβ expression.
Front Vet Sci
November 2023
Article Synopsis
- Diabetes mellitus is a metabolic syndrome affecting spleen function and can be influenced by medicinal plants like okra, which may have potential anti-diabetic effects.
- Research was conducted on diabetic rats to analyze the impact of okra pod extract on biochemical parameters, immune cell expression (CD8 T cells), and inflammatory markers (NF-kB and cytokines) in the spleen.
- The study found that diabetes negatively impacted the rats' health, leading to weight loss, high blood glucose, and significant alterations in spleen tissue structure, highlighting the need for further investigation into the therapeutic effects of okra.
In this study, the probable alleviative role of curcumin (CMN) (50 mg/kg b.wt) or curcumin-loaded chitosan nanoparticle (CLC-NP) (50 mg/kg b.wt) was assessed against the hepatotoxic effect of a widely used pyrethroid insecticide, fenpropathrin (FEN) (15 mg/kg b.
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