Protective association of A-T-T haplotype of DMT1 gene against risk of human age-related nuclear cataract.

Background: Age-related cataract (ARC) is profoundly associated with oxidative stress. Iron plays a pivotal role in generating oxidative stress and promoting deleterious irreversible damage to the macromolecules. Divalent metal transporter 1 (DMT1) mediates the uptake of iron into the cell.

Association of -p.Ala170Ala and -p.Ile95Ile Polymorphisms with Congenital Cataract and Microphthalmia.

Purpose: To investigate the association of -p.Ala170Ala (rs34082359) and -p.Ile95Ile (rs2281983) polymorphisms with congenital cataract and microphthalmia in a western Indian population.

Trichostatin A Restores Expression of Adherens and Tight Junction Proteins during Transforming Growth Factor β-Mediated Epithelial-to-Mesenchymal Transition.

Purpose: Adherens junctions and polarity markers play an important role in maintaining epithelial phenotype but get altered during the epithelial-mesenchymal transition (EMT). Alterations of these markers during EMT of lens epithelial cell (LEC) can lead to vision compromising conditions. The aim of this study was to examine if Trichostatin-A (TSA), a histone deacetylase inhibitor, can prevent EMT by restoring the adherens junction complex in LEC.

Genetic investigation of ocular developmental genes in 52 patients with anophthalmia/microphthalmia.

Background: Mutation in eye developmental genes has been reported to cause anophthalmia and microphthalmia. However, in India, especially in the Western Indian population, such reports are scarce. Hence, the present study aims to investigate mutations in 15 ocular developmental genes in patients with anophthalmia and microphthalmia in the western region of India.