Publications by authors named "Naina Kohli"
E-cigarette/vaping-associated lung injury (EVALI) is strongly associated with vitamin E acetate and often occurs with concomitant tetrahydrocannabinol (THC) use. To uncover pathways associated with EVALI, we examined cytokines, transcriptomic signatures, and lipidomic profiles in bronchoalveolar lavage fluid (BALF) from THC-EVALI patients. At a single center, we prospectively enrolled mechanically ventilated patients with EVALI from THC-containing products (N = 4) and patients with non-vaping acute lung injury and airway controls (N = 5).
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- - The study focused on KPC-Kp bloodstream infections, which are deadly, and aimed to understand how these bacteria resist a key defense mechanism in our blood, called complement.
- - Researchers tested various KPC-Kp isolates from patients, discovering that 27% of them resisted killing by human serum; a specific gene mutation (wcaJ) linked to capsule production contributed to this resistance.
- - This mutation resulted in less capsule presence, paradoxically increasing the bacteria's ability to bind complement proteins while also improving their survival against immune responses, potentially allowing them to thrive in the bloodstream without being overly virulent in tissues.
Article Synopsis
- *Researchers found that 27% of KPC-Kp isolates showed increased resistance to human serum, linked to a mutation that reduces capsule content and helps the bacteria evade immune responses.
- *The mutation allows KPC-Kp to survive better in the bloodstream while being less virulent in tissues, highlighting a complex interaction that aids the bacteria's persistence in the host.
Phagocytosis is a primary determinant of pulmonary clearance of clinical isolates.
Front Cell Infect Microbiol
April 2023
Introduction: () is a common cause of hospital-acquired pneumonia. Although previous studies have suggested that evasion of phagocytic uptake is a virulence determinant of , few studies have examined phagocytosis sensitivity in clinical isolates.
Methods: We screened 19 clinical respiratory isolates that were previously assessed for mucoviscosity for their sensitivity to macrophage phagocytic uptake, and evaluated phagocytosis as a functional correlate of pathogenicity.
Study Objectives: Sleep quantity and continuity vary across the lifespan. Actigraphy is a reliable and widely used behavioral measure of sleep in research and personal health monitoring. This meta-analysis provides a novel examination of whether age (in years) is associated with actigraphy-assessed sleep across the lifespan.
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