Discovery of Therapeutic Lead Molecule Against β-Tubulin Using Computational Approach.

Virtual screening strategy was performed against the target β-tubulin to overcome paclitaxel resistance in blood cancer types. In essence, A185T and A248V are two such important mutations frequently observed in clinical trials that confer paclitaxel resistance. In the present investigation, compounds from NPACT database were filtered by pharmacokinetics, toxicity and binding energy values.

Uveal Melanoma Mimicking Advanced Coats' Disease in a Young Patient.

Background/aims: To report a case and the unique histopathology of a necrotic uveal melanoma mimicking advanced Coats' disease in a young adult.

Method: A 26-year-old male presented with a blind, painful eye, total exudative retinal detachment, and bulbous aneurysms consistent with Coats' disease. No masses were visualized on ultrasound or CT scan, and the patient underwent enucleation of the eye.

Rate of hypotony following 25-gauge pars plana vitrectomy.

Background And Objective: To report the rates of hypotony after 25-gauge vitrectomy.

Patients And Methods: A retrospective review of 111 consecutive cases was performed in patients undergoing transconjunctival 25-gauge pars plans vitrectomy with either air or gas as a tamponade agent. The primary outcome measure was postoperative intraocular pressure less than 5 mm Hg.

Resolution of a choroidal abscess in the setting of endophthalmitis in an immunocompetent host with noninvasive treatment.

Purpose: The purpose of this article was to report a case of Pseudomonas aeruginosa-related endophthalmitis associated with a choroidal abscess in an immunocompetent patient, with no history of lung disease or surgery that responded to noninvasive treatment and to compare it with other reported cases of P. aeruginosa-related choroidal abscesses.

Methods: A case report.

Oral rifampin utilisation for the treatment of chronic multifocal central serous retinopathy.

Chronic central serous retinopathy (CSR) is characterised by frequent exacerbations and a poor visual prognosis. Very few therapies exist for chronic CSR, and the existing therapies are often ineffective. Thus, novel therapies to combat this frustrating disorder are needed.