Publications by authors named "Nailya R Makhmudova"
Article Synopsis
- Influenza viruses can interact with Staphylococcus aureus, increasing the risk of severe bacterial pneumonia, a leading cause of death during influenza outbreaks, especially since there is no vaccine for S. aureus and antibiotic resistance is growing.
- The study tested a vaccine using virus-like particles (VLP) that expressed an influenza protein in mice, finding that a single low dose could help prevent severe bacterial infections after influenza.
- However, while the vaccine generated a strong immune response against the influenza virus, it wasn't enough to stop the replication of different strains of the virus or protect against subsequent bacterial infections, indicating that more comprehensive strategies may be needed.
Antiviral drugs can play a significant role in the control of influenza. Umifenovir (Arbidol) is licensed and widely used in Russia for the prophylaxis and/or treatment of influenza. We evaluated the susceptibility to umifenovir of reference influenza A and B viruses and influenza A viruses isolated from patients in the ARBITR clinical trial in 2012-2014 seasons.
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