Publications by authors named "Nailong Gao"
Background: Although the antitumor efficacy of docetaxel (DTX) has long been attributed to the antimitotic activities, its impact on the tumor microenvironment (TME) has recently gained more attention. Macrophages are a major component of the TME and play a critical role in DTX efficacy; however, the underlying action mechanisms remain unclear.
Methods: DTX chemotherapeutic efficacy was demonstrated via both macrophage depletion and C-C motif chemokine ligand 3 (Ccl3)-knockout transgenic allograft mouse model.
Sealing is one of the important technologies of a self-driving microfluidic chip. To achieve a better sealing effect, a sealing device based on capillary force is proposed in this paper. The device is composed of a cover plate, a partition plate and a bottom plate; the surface of the microchannel is flat.
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- Rhubarb is a traditional herbal medicine recognized for its anti-cancer properties, but recent studies indicate that it may also cause liver toxicity, highlighting the need for further research on its safety in treating liver cancer.
- The study specifically examined Rhubarb's dual effects—either protecting or harming the liver—using a rat model to assess its impact during the development of liver cancer induced by diethylnitrosamine (DEN).
- Findings showed that Rhubarb altered metabolic pathways in the liver, particularly by activating glucose 6 phosphate dehydrogenase (G6PD), which suggests a complex role in liver function during cancer treatment.
Alpha-fetoprotein (AFP) is an important disease biomarker, relating to cancers such as hepatocarcinomas and gastric cancer. However, traditional methods are time-consuming, relied on bulky instruments and trained professionals, cannot satisfy the demand for low cost and point-of-care testing (POCT). In this study, a power-free POCT device was developed for the rapid and low-cost detection of AFP via one-sampling.
View Article and Find Full Text PDFA microfluidic chip based on capillary infiltration was designed to detect tumor markers. Serum samples flowed along a microchannel that used capillary force to drive sample injection, biochemical reactions and waste liquid collection. This permitted us to realize rapid qualitative detection of tumor markers and other biological molecules.
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