Publications by authors named "Naila Aba"
Background: Cardiac disease (CD) is a primary long-term diagnosed pathology among childhood cancer survivors. Dosiomics (radiomics extracted from the dose distribution) have received attention in the past few years to assess better the induced risk of radiotherapy (RT) than standard dosimetric features such as dose-volume indicators. Hence, using the spatial information contained in the dosiomics features with machine learning methods may improve the prediction of CD.
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- Identifying key risk factors in childhood cancer survivors is crucial for improving treatment and follow-up care to reduce long-term mortality.
- A study of 7,670 childhood cancer survivors revealed that subsequent cancers, severe heart conditions, and radiotherapy significantly impact Life Years Lost.
- Radiotherapy was identified as a major cause of early death, highlighting the need for ongoing monitoring of patients who develop additional health issues post-treatment.
Genetic Risk of Second Malignant Neoplasm after Childhood Cancer Treatment: A Systematic Review.
Cancer Epidemiol Biomarkers Prev
August 2024
Article Synopsis
- Second malignant neoplasm (SMN) poses a significant long-term risk for childhood cancer survivors and is influenced by genetic factors, alongside traditional treatments like chemotherapy and radiotherapy.
- A systematic review analyzed eighteen studies exploring genetic components linked to SMN risk, encompassing various cancer types and focusing mainly on genes related to drug metabolism and DNA repair.
- The variability in study designs and methods highlights the need for more standardized research, but the review offers a useful compilation of genetic variants associated with SMN risk, aiding future investigations.