Publications by authors named "Naif Almuqati"
The search for effective anti-cancer therapies has led to the exploration of dual inhibition strategies targeting multiple key molecular pathways. In this study, we aimed to design a novel candidate capable of dual inhibition targeting both EGFR (Epidermal Growth Factor Receptor) and PARP-1 (poly(ADP-ribose)polymerase-1), two crucial proteins implicated in cancer progression and resistance mechanisms. Through molecular hybridization and structure-based drug design approaches, we synthesized a series of compounds based on spirooxindole with triazole scaffolds with the potential for dual EGFR and PARP-1 inhibition.
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- The study investigates the use of Ni-based catalysts on titania-zirconia to achieve high hydrogen (H) yield and H/CO ratios through partial oxidation of methane (POM) at 600 °C.
- The addition of 2.5 wt% strontium (Sr) to the catalyst significantly improved performance by enhancing the formation of active sites, leading to 45% CH conversion and 47% H yield with a H/CO ratio of 3.5.
- Further optimization of the process led to predicted and validated results of approximately 88% CH conversion and 86-87% H yield at higher temperatures and specific conditions.
A novel catalyst for the reduction of 4-nitrophenol (4-NP) was prepared using carboxyl group-functionalized multiwalled carbon nanotubes (MWCNTs), polymer matrix, and silver nanoparticles (AgNPs). The AgNPs were prepared by the reduction of silver nitrate by trisodium citrate in the MWCNTs-polymer nanocomposite; the size of the synthesized AgNPs was found to be 3nm (average diameter). The synthesized nanocomposites were characterized using several analytical techniques.
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