Publications by authors named "Naiara Maran"
Host resistance to visceral leishmaniasis: prevalence and prevention.
Expert Rev Anti Infect Ther
December 2016
Visceral leishmaniasis (VL) is a chronic parasitic disease caused by the vector-borne Leishmania donovani and Leishmania (L.) infantum chagasi parasites. The disease affects about 12 million humans in more than 90 countries worldwide.
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- - Leishmaniasis is a tropical disease caused by Leishmania protozoa, transmitted by sand flies, with visceral leishmaniasis being the most severe and dangerous form, noted for its high mortality and morbidity.
- - In a study with CD43⁺/⁺ and CD43⁻/⁻ mice infected with Leishmania, results showed that CD43⁻/⁻ mice were more susceptible to the infection, exhibiting higher parasite levels and weakened immune responses.
- - The research concluded that CD43 plays a significant role in enhancing host resistance against visceral leishmaniasis by promoting certain T cell responses and increasing the production of protective cytokines like IFN-γ.
Background: Kinins liberated from plasma-borne kininogens, are potent innate stimulatory signals. We evaluated whether resistance to infection by Leishmania (L.) chagasi depends on activation of G-protein coupled bradykinin B2 receptors (B2R).
View Article and Find Full Text PDFThe thymus is a primary lymphoid organ in which bone marrow-derived T-cell precursors undergo differentiation, leading to migration of positively selected thymocytes to the T-cell-dependent areas of secondary lymphoid organs. This organ can undergo atrophy, caused by several endogenous and exogenous factors such as ageing, hormone fluctuations, and infectious agents. This paper will focus on emerging data on the thymic atrophy caused by infectious agents.
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