[Structural identification and quality study on isomers of a novel anticancer photosensitiser photocyanine].

Our work focuses on the quality control and structural identification of Photocyanine as a cancer therapeutic photosensitizer. Photocyanine is a mixture which contains four ZnPcS2P2 type substituted Phthalocyanine isomers. In order to obtain the single component from Photocyanine, the mixture of four isomers possessing the similar structures and chemical property had been isolated and purified.

[Study on UV-Vis absorption spectra and fluorescence emission spectra of sixteen tetra-substituted metallophthalocyanine complexes].

The UV-Visible absorption spectra and the fluorescence emission spectra of sixteen tetra-substituted metallo-phthalocyanine complexes {R4 PcM, where R = 2-[4-(2-sulfonic ethyl) piperazin-1-] ethoxyl (SPEO--), 2-(piperidin-1-yl) ethoxyl (PEO--); substitution position at alpha-position and beta-position of phthalocyanine ring; M = Zn(II), Ni(II), Co(II) and Cu(II)} were measured. The influence of different central ion, substituted group and its position, as well as different solvent on the Q-band of phthalocyanine complex in its UV-Vis absorption spectra was investigated. The influence of different central ion, substituted group and its position on the fluorescence emission spectra was discussed.

[Fluorescence spectra and photo-generating rate of singlet oxygen of phthalocyaninatopalladium].

The absorption spectral properties, fluorescence spectral properties and the abilities of photo-generating singlet oxygen of four phthalocyanines, namely tetra-alpha-(2,2,4-trimethyl-3-pentoxy) phthalocyaninatopalladium (zinc) and tetra-alpha-(2,4-diterbutylphenoxy) phthalocyaninatopalladium (zinc), were determined. Experimental results show that the ability of photo-generating singlet oxygen of phthalocyaninatopalladium is similar to that of phthalocyaninatozincx, though palladium(II) is an open shell electron structure and zinc( II ) is a closed shell structure. This may be concerned with a weak flourescence intensity and a strong inter-crossing transition of phthalocyaninatopalladium.

[Meso-tetraphenylporphyrinatozinc/TiO2 nanocompound synthesized by in-situ method and photocatalysis under visible-light irradiation].

The meso-tetraphenylporphyrinatozinc/titanium dioxide (ZnTPP/TiO2) nanocompounds with different molar ratios were synthesized by sol-gel method at 400 degrees C, 4h. The nanocompounds were characterized by XRD, UV-Vis, FTIR and Fluorescence methods. Anatase for TiO2 in the nanocompounds was defined, and ZnTPP was also obtained during in-situ process.

[Study on UV-Vis absorption spectra of tetra-azo-aromaticoxy substituted metallophthalocyanines].

UV-Vis absorption spectras of six series (18 kinds) of tetra- azo-aromaticoxy substituted metallophthalocyanines (R4 PcM, R = 4-pyridyloxy, 8-quinolinoxy, 2-methyl-8-quinolinoxy; substitution position: a position and beta position; M = Ni (II), Cu(II), Zn(II)) were measured. The effects of central mentals, the kinds and the positions of substitution groups, and solvents on the metallophthalocyanines' lamdamax in Q-band were discussed. Experimental data show: The lamdamax in Q-band of title complexes is about 680 nm.

2-Benzyl-isoindoline-1,3-dione: a monoclinic polymorph.

In the molecule of the title compound, C(15)H(11)NO(2), the dihedral angle between the ring systems is 81.3 (2)°. In the crystal structure, mol-ecules are held together via C-H⋯O inter-actions.

[Synthesis and UV/Vis spectra of a dialkyloxy substituted phthalocyanine].

A dialkyloxy substituted metal-free phthalocyanine was synthesized by using 3-(2',2',4'-trimethyl-3'-pentoxy)-1,3-diiminoisoindoles and 1,3,3-trichloroisoindolenine as starting materials, and characterized by element analysis, 1H NMR, IR and UV/Vis spectra. The dependences of wavelength of UV/Vis spectra and its split of Q band absorption on the number of substituents and, dielectric constant of solvents are discussed based on the comparison with tetraalkyloxy substituted metal-free phthalocyanine.

[A silicon phthalocyanine axially substituted by nipagin: synthesis, molecular spectroscopic properties, and in vitro photodynamic activities].

A new silicon phthalocyanine axially substituted by Nipagin, i.e. bis(4-methoxycarboxyl phenoxy)phthalocyaninatosilicon, has been synthesized and characterized by IR, NMR, HPLC and elemental analysis.

[Determination and pharmacokinetics of photosensitizer ZnPcS2P2 uptaken by K562 cells].

The di-sulfonated di-phthalimidomethyl phthalocyanine zinc (ZnPcS2P2) was an amphiphilic photosensitizer for photodynamic therapy of cancer. According to fluorescence analytical method, extracting efficiencies of 2.0% SDS (Wt%), 1.

Syntheses of Metal Phthalocyanines and Their Photoinactivations on Cancer Cells.

This paper reported the syntheses of amphiphilic substituted metal phthalocyanines containig sulfonic acid groups and phthalimidomethyl groups (MPcSP, M=Zn or Al(OH), S=-SO(3)(-), P=phthalimidomethyl). We have selected zinc phthalocyanine (Zn-D) as the one with better cell killing potential by an in vitro cell survival assay. Over 90 % tumor cells were killed with 10 mg/L Zn-D, after they were exposed to 12 J/cm(2) red light.