Publications by authors named "Nai-liang Tian"

Background: It is currently uncertain whether the combination of a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor and high-intensity statin treatment can effectively reduce cardiovascular events in patients with acute coronary syndrome (ACS) who have undergone percutaneous coronary intervention (PCI) for culprit lesions.

Methods: This study protocol describes a double-blind, randomized, placebo-controlled, multicenter study aiming to investigate the efficacy and safety of combining a PCSK9 inhibitor with high-intensity statin therapy in patients with ACS following PCI. A total of 1,212 patients with ACS and multiple lesions will be enrolled and randomly assigned to receive either PCSK9 inhibitor plus high-intensity statin therapy or high-intensity statin monotherapy.

View Article and Find Full Text PDF

Background: Acute kidney injury (AKI) is common after cardiac interventional procedures. The prevalence and clinical outcome of AKI in patients with acute myocardial infarction (AMI) after undergoing intra-aortic balloon pump (IABP) implantation remains unknown. The aim of this study was to investigate the incidence, risk factors, and prognosis of AKI in specific patient populations.

View Article and Find Full Text PDF

What Is Known And Objective: It is well known that high in-stent thrombotic risk due to the superimposition of a platelet-rich thrombus was considered as the main origin of major adverse cardiac events after stent implantation. The clinical management of antiplatelet therapy strategy after percutaneous coronary intervention (PCI) remains controversial. This study is sought to explore the efficacy and safety of a maintained P2Y inhibitor monotherapy after shorter-duration of dual antiplatelet therapy (DAPT) in these patients.

View Article and Find Full Text PDF

Background: Ventricular septal rupture (VSR) is a severe mechanical complication secondary to acute myocardial infarction (AMI) with a dreadful prognosis. The goal of our study was to evaluate the mortality and to identify the predictors of mortality for this population.

Methods: From June 2012 to July 2021, patients with VSR secondary to AMI were initially screened for eligibility in this study.

View Article and Find Full Text PDF
Article Synopsis
  • Current guidelines recommend 12 months of dual antiplatelet therapy (DAPT) for acute coronary syndrome (ACS) patients after drug-eluting stent (DES) implantation, but recent studies suggest that 3 months of DAPT followed by ticagrelor alone might also be effective and safe.
  • The IVUS-ACS and ULTIMATE-DAPT trial aims to compare the safety and effectiveness of IVUS-guided versus angiography-guided DES implantation and to evaluate the impact of ticagrelor monotherapy versus ticagrelor plus aspirin on bleeding risks and major adverse cardiovascular events over a year following the procedure.
  • The study will involve 3,486 ACS patients who
View Article and Find Full Text PDF
Article Synopsis
  • This study compared target vessel failure (TVF) rates 3 years after drug-eluting stent (DES) implantation using either intravascular ultrasound (IVUS) guidance or angiographic guidance.
  • Results showed that IVUS guidance led to lower TVF rates (6.6%) compared to angiography (10.7%), primarily due to fewer clinically driven target vessel revascularizations.
  • Additionally, the incidence of stent thrombosis was also significantly lower in the IVUS group (0.1%) versus the angiography group (1.1%).
View Article and Find Full Text PDF

Background: Double kissing (DK) crush approach for patients with coronary bifurcation lesions, particularly localized at distal left main or lesions with increased complexity, is associated with significant reduction in clinical events when compared with provisional stenting. Recently, randomized clinical trial has demonstrated the net clinical benefits by intravascular ultrasound (IVUS)-guided implantation of drug-eluting stent in all-comers. However, the improvement in clinical outcome after DK crush treatment guided by IVUS over angiography guidance for patients with complex bifurcation lesions have never been studied in a randomized fashion.

View Article and Find Full Text PDF

Aim: The present study aimed to assess the benefits of two-stent techniques for patients with DEFINITION criteria-defined complex coronary bifurcation lesions.

Methods And Results: In total, 653 patients with complex bifurcation lesions at 49 international centres were randomly assigned to undergo the systematic two-stent technique (two-stent group) or provisional stenting (provisional group). The primary endpoint was the composite of target lesion failure (TLF) at the 1-year follow-up, including cardiac death, target vessel myocardial infarction (TVMI), and clinically driven target lesion revascularization (TLR).

View Article and Find Full Text PDF

Background: Stent failure is more likely in the lipid rich and thrombus laden culprit lesions underlying ST-segment elevation myocardial infarction (STEMI). This study assessed the effectiveness of post-dilatation in primary percutaneous coronary intervention (pPCI) for acute STEMI.

Methods: The multi-center POST-STEMI trial enrolled 41 consecutive STEMI patients with symptom onset <12 hours undergoing manual thrombus aspiration and Promus Element stent implantation.

View Article and Find Full Text PDF

Background: The efficacy and safety of ticagrelor following percutaneous coronary intervention for patients with acute coronary syndrome remains unclear. This study sought to evaluate clinical outcomes of ticagrelor as part of dual-antiplatelet treatment for these patients.

Methods: PubMed, MEDLINE, Embase, and other Internet sources were searched for eligible citations.

View Article and Find Full Text PDF

Stenting coronary artery bifurcation lesion is associated with suboptimal clinical results. Clinical improvement by intravascular ultrasound (IVUS) guided bifurcation stenting is controversial because small-side-branch (SB), low-risk patients and false bifurcations were included in previous studies that had no exact IVUS criteria for optimal stent expansion. We sought determine whether IVUS guidance is superior to angiography guidance for patients with true and complex bifurcation lesions.

View Article and Find Full Text PDF

Background: The relationship between obstructive sleep apnea (OSA) and platelet reactivity in patients undergoing percutaneous coronary intervention (PCI) has not been defined. The present prospective, single-center study explored the relationship between platelet reactivity and OSA in patients with PCI.

Methods: A total of 242 patients were finally included in the study.

View Article and Find Full Text PDF
Article Synopsis
  • The study compares provisional stenting (PS) and a two-stent technique for treating complex coronary bifurcation lesions (CBLs) in patients, addressing a gap in current research.
  • A total of 660 patients will be randomly assigned to either PS or the two-stent method, with the main goal being to evaluate 12-month target lesion failure rates and various secondary outcomes.
  • The trial has received ethical approval and aims to share findings through peer-reviewed publications and conferences.
View Article and Find Full Text PDF
Article Synopsis
  • miRNA-210 is implicated in enhancing angiogenesis and has a potentially therapeutic role in treating acute myocardial infarction (AMI).
  • In AMI models, increasing miRNA-210 levels led to higher expression of hepatocyte growth factor (HGF) and improved microvessel density in heart tissue, indicating enhanced blood vessel formation.
  • The study found that miRNA-210 agonists also improved cardiac function in rats by enhancing contractility, as suggested by better left ventricular performance metrics.
View Article and Find Full Text PDF

Type 2 diabetes correlates with clinical events after the implantation of a second-generation drug-eluting stent (DES). The rate and prognostic value of stent fracture (SF) in patients with diabetes who underwent DES implantation remain unknown. A total of 1160 patients with- and 2251 without- diabetes, who underwent surveillance angiography at 1 year after DES implantation between June 2004 and August 2014, were prospectively studied.

View Article and Find Full Text PDF

Objectives: This study aimed to investigate the cutoff of post-drug-eluting stent (DES) fractional flow reserve (FFR) for prediction of 1- to 3-year target vessel failure (TVF).

Background: FFR immediately after a DES implantation correlates with clinical events. However, the cutoff of post-DES FFR for predicting long-term clinical events remains understudied.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the impact of intravascular ultrasound (IVUS)-guided drug-eluting stent (DES) implantation on patients with complex coronary artery lesions, focusing on major adverse cardiac events (MACE) as the primary outcome.
  • Results from 15 clinical trials with over 8,000 patients indicate a significant reduction in MACE risk when using IVUS guidance compared to conventional coronary angiography, especially noting lower risks for all-cause mortality, myocardial infarction, and target-vessel revascularization.
  • The conclusion suggests that IVUS guidance is beneficial for patients with complex lesions, particularly those with left main disease or bifurcation lesions, but further large-scale randomized trials are needed to solidify
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to determine the impact of high platelet reactivity (HPR) on clinical outcomes, specifically stent thrombosis, in patients who received drug-eluting stents (DESs).
  • It found that patients with HPR on aspirin had a significantly higher incidence of stent thrombosis (9.9%) compared to those without (0.4%), and similar results were noted for clopidogrel (3.0% vs. 0.1%).
  • The study concluded that HPR is linked to an increased risk of stent thrombosis and major adverse cardiovascular and cerebrovascular events, particularly all-cause death and myocardial infarction, but did not find differences in bleeding
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the effectiveness of triple antiplatelet treatment (TAPT), which includes cilostazol with aspirin and clopidogrel, in patients with complex coronary artery lesions or acute coronary syndrome (ACS).
  • Results from 11 trials with 9,553 patients showed that TAPT significantly reduced major adverse cardiac events (MACE) and all-cause mortality in ACS patients without increasing bleeding risks.
  • Researchers conclude that TAPT may offer benefits for ACS patients post-stent implantation, but further large-scale randomized studies are needed to confirm its advantages.
View Article and Find Full Text PDF

Background: There is a paucity of evidence regarding the association between obstructive sleep apnea (OSA) and patients undergoing percutaneous coronary intervention (PCI) for coronary artery disease. We sought to investigate whether OSA affects the clinical outcomes of patients undergoing PCI.

Patients And Methods: All enrolled individuals treated with PCI were evaluated for OSA by polysomnography.

View Article and Find Full Text PDF

Background: The effects of intra-aortic balloon pump (IABP) usage in patients with acute myocardial infarction remain controversial. This study sought to evaluate the outcomes of IABP usage in these patients.

Methods: Medline, EMBASE, and other internet sources were searched for relevant clinical trials.

View Article and Find Full Text PDF

Objectives: The present study aimed to analyze the incidence of SF and its correlation with clinical events after DES implantation and the outcome of re-intervention for symptomatic in-stent restenosis (ISR) induced by stent fracture (SF).

Background: SF is associated with a high rate of clinical events after the implantation of drug-eluting stents (DES). However, the chronological rate of SF and the effect of SF on clinical outcomes from a large patient population remain underreported.

View Article and Find Full Text PDF

Objective: This study investigated the diagnostic accuracy of three-dimensional quantitative coronary angiography (3D-QCA) compared with conventional 2D-QCA for predicting functional severity assessed by fractional flow reserve (FFR) for true bifurcation lesions.

Methods: Based on pooled data from the randomized DK-CRUSH II, III, and IV trials, we evaluated the patients with true bifurcation lesions who underwent coronary angiography together with functional evaluations using FFR in both the main vessel and the side branch. Off-line 2D- and 3D-QCA analyses were conducted using dedicated bifurcation QCA analysis software.

View Article and Find Full Text PDF

Aims: The study aimed to examine five-year clinical outcomes of complete (CR), partially complete (PCR), and incomplete revascularisation (ICR) in patients with unprotected left main coronary artery (ULMCA) disease treated with drug-eluting stents (DES). Completeness of revascularisation, defined as revascularisation of all vessels ≥1.5 or 2.

View Article and Find Full Text PDF

Aims: This study sought to compare angiographic endpoints at one-year follow-up after a drug-eluting stent implantation guided by either intravascular ultrasound (IVUS) or angiography in patients with chronic total occlusion (CTO) lesions.

Methods And Results: Patients with at least one CTO lesion recanalised successfully were randomly assigned to the IVUS-guided or the angiography-guided group. The use of IVUS for penetration of the true lumen and optimisation of stent expansion was only done in the IVUS-guided group.

View Article and Find Full Text PDF