Development of a yeast cell based method for efficient screening of high yield tacrolimus production strain.

Unlabelled: Tacrolimus (FK506) is a widely used and clinically important immunosuppressant drug that can be produced by fermentation of . The industrial strains are typically obtained through multiple rounds of mutagenesis and screening, a labor-intensive process. We have established an efficient yeast cell based screening method for the evolutionary process of high-FK506-yielding strain.