Publications by authors named "Nai-Fei Chen"
Nutritional symbionts influence host reproduction, but the underlying molecular mechanisms are largely unclear. We previously found that the bacteriocyte symbiont Hamiltonella impacts the sex ratio of the whitefly Bemisia tabaci. Hamiltonella synthesizes folate by cooperation with the whitefly.
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- This study explores the use of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) to treat neonatal brain injuries caused by maternal immune activation.
- Researchers created rat models of brain injury by exposing pregnant rats to a substance that triggers immune responses, then administered hUC-MSCs to the offspring.
- The results showed that hUC-MSCs reduced inflammation and improved brain function by inhibiting a specific protein (PTBP-1) and enhancing astrocyte activity, suggesting a potential therapy for neurodevelopmental disorders.
Immunotherapy has opened a new era in cancer treatment. Drugs represented by immune checkpoint inhibitors have led to important breakthroughs in the treatment of various solid tumors, greatly improving the survival rate of cancer patients. Many types of immunotherapeutic drugs have become widely available; however, their efficacy is variable, and relatively few patients with advanced cancer experience life-altering durable survival, reflecting the complex and highly regulated nature of the immune system.
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