Publications by authors named "Nai Guo Si"
Article Synopsis
- The study focuses on the type III secretion system (T3SS) in Gram-negative bacteria, which is crucial for their virulence and a potential target for new anti-virulence drugs.
- Researchers developed a screening system to test 12,000 chemical compounds for their ability to inhibit T3SS, leading to the discovery of benzyloxy carbonimidoyl dicyanide (BCD) derivatives that effectively block T3SS activity.
- The compound BCD03 was notably effective in reducing the pathogenicity of specific bacterial strains on melon seedlings and inhibited effector secretion, making it a promising candidate for controlling plant bacterial infections.
ABSTRACT The mechanism of the effects of flumorph (a novel fungicide) was investigated by analyzing alterations of hyphal morphology, cell wall deposition patterns, F-actin organization, and other organelles in Phytophthora melonis. Calcofluor white staining suggested that flumorph did not inhibit the synthesis of cell wall materials, but disturbed the polar deposition of newly synthesized cell wall materials during cystospore germination and hyphal growth. After exposure to flumorph, zoospores were able to switch into cystospores accompanied with the formation of a cell wall, whereas cystospores failed to induce the isotropic-polar switch and did not produce germ tubes but continued the isotropic growth phase.
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