Publications by authors named "Nahua Xu"
Cisplatin plays a pivotal role in the chemotherapy treatment of various cancers, but its use is often limited due to its nephrotoxic side effects. Identifying compounds that can mitigate cisplatin-induced nephrotoxicity is therefore of great importance. This study focused on evaluating the protective effects of reserpine against cisplatin-induced acute kidney injury.
View Article and Find Full Text PDFArticle Synopsis
- Ferroptosis is an iron-dependent cell death process linked to various diseases, making its inhibition potentially useful for treating conditions like drug-induced liver injury (DILI).
- The study identifies the drug mifepristone (RU486) as a new ferroptosis inhibitor, which works by enhancing the synthesis of glutathione (GSH) and promoting detoxification pathways that help protect cells from ferroptotic death.
- RU486 shows significant protective effects in a mouse model of acetaminophen-induced liver injury, demonstrating its potential as a therapeutic option through mechanisms involving NRF2 and other detoxification pathways independent of traditional ferroptosis systems.