Publications by authors named "Naho Nishinakama"
BMC Infect Dis
October 2024
Article Synopsis
- Francisella tularensis, the bacterium causing tularemia, is usually studied in immune cells, but gene editing in these cells is challenging, leading researchers to explore HeLa epithelial cells instead.
- A new model using HeLa cells expressing mouse FcγRII (HeLa-FcγRII) was developed, showing a significant increase in infection rates of F. novicida, up to 100 times more than regular HeLa cells.
- Gene silencing experiments revealed that knocking down GLS1 (glutaminase) in HeLa-FcγRII cells increased cell death during infection, suggesting that ammonia produced from glutaminase is crucial for F. novicida's growth.
