Gold(III)-Catalyzed Propargylic Substitution Reaction Followed by Cycloisomerization for Synthesis of Poly-Substituted Furans from -Tosylpropargyl Amines with 1,3-Dicarbonyl Compounds.

The treatment of -tosylpropargyl amines with 1,3-dicarbonyl compounds in the presence of AuBr (5 mol%) and AgOTf (15 mol%) afforded poly-substituted furans in good-to-high yields via the gold-catalyzed cleavage of the sp carbon-nitrogen bond.