Data from X-ray crystallographic analysis and DFT calculations on isomeric azo disperse dyes.

X-ray crystallography and DFT calculations were used to characterize the molecular nature and excited state properties of isomeric photostable azo dyes for textile fibers undergoing extensive sunlight exposure. Structural data in CIF files arising from X-ray analysis are reported and the complete files are deposited with the Cambridge Crystallographic Data Centre as CCDC 1548989 (https://www.ccdc.

Developments in PDT Sensitizers for Increased Selectivity and Singlet Oxygen Production.

Photodynamic therapy (PDT) is a minimally-invasive procedure that has been clinically approved for treating certain types of cancers. This procedure takes advantage of the cytotoxic activity of singlet oxygen (¹O₂) and other reactive oxygen species (ROS) produced by visible and NIR light irradiation of dye sensitizers following their accumulation in malignant cells. The main two concerns associated with certain clinically-used PDT sensitizers that have been influencing research in this arena are low selectivity toward malignant cells and low levels of ¹O₂ production in aqueous media.

In vitro modulation of TCF7L2 gene expression in human pancreatic cells.

Several studies have recently reported strong association between type 2 diabetes and variation in the transcription factor 7-like 2 (TCF7L2) gene, which has been confirmed by several other genome-wide studies. However, the physiological implications of this transcription factor on the pathogenesis of type 2 diabetes is not yet known. The aim of this study was to investigate the alteration in TCF7L2 gene expression in human pancreatic cell line in response to various factors in vitro.

Adenosine deaminase gene polymorphism is associated with obesity in Iranian population.

Objective: Adenosine deaminase (ADA) is a polymorphic enzyme which has an important role in modulation of insulin bioactivity. It has been suggested that an excess of adenosine A1 receptor activity may contribute to adiposity in type 2 diabetes. Adenosine seems to have a role in facilitating insulin action on the adipocytes.