Development of Enterovirus Antiviral Agents That Target the Viral 2C Protein.

The Enterovirus (EV) genus includes several important human and animal pathogens. EV-A71, EV-D68, poliovirus (PV), and coxsackievirus (CV) outbreaks have affected millions worldwide, causing a range of upper respiratory, skin, and neuromuscular diseases, including acute flaccid myelitis, and hand-foot-and-mouth disease. There are no FDA-approved antiviral therapeutics for these enteroviruses.

The-state-of-the-art of soft robotics to assist mobility: a review of physiotherapist and patient identified limitations of current lower-limb exoskeletons and the potential soft-robotic solutions.

Background: Soft, wearable, powered exoskeletons are novel devices that may assist rehabilitation, allowing users to walk further or carry out activities of daily living. However, soft robotic exoskeletons, and the more commonly used rigid exoskeletons, are not widely adopted clinically. The available evidence highlights a disconnect between the needs of exoskeleton users and the engineers designing devices.

Linking farm production diversity to household dietary diversity controlling market access and agricultural technology usage: evidence from Noakhali district, Bangladesh.

Background And Objective: Diversified agricultural production is considered a means to enhance food diversity at the household level, particularly in developing countries where subsistence farming is common. Given the importance of a diversified diet for human health and the persistent malnutrition problem in Bangladesh, a pressing issue is how different crops and livestock production affect household food diversification, and this study sought to answer that question.

Methods: Using a multistage sampling procedure, data were collected from 190 small farm holder households from Hatiya (a coastal rural sub-district of Noakhali, Bangladesh).

Image Guided Mitral Valve Replacement: Registration of 3D Ultrasound and 2D X-ray Images.

Mitral valve repair or replacement is important in the treatment of mitral regurgitation. For valve replacement, a transcatheter approach had the possibility of decrease the invasiveness of the procedure while retaining the benefit of replacement over repair. However, fluoroscopy images acquired during the procedure provide no anatomical information regarding the placement of the probe tip once the catheter has entered a cardiac chamber.

Towards FBG-Based Shape Sensing for Micro-scale and Meso-Scale Continuum Robots with Large Deflection.

Endovascular and endoscopic surgical procedures require micro-scale and meso-scale continuum robotic tools to navigate complex anatomical structures. In numerous studies, fiber Bragg grating (FBG) based shape sensing has been used for measuring the deflection of continuum robots on larger scales, but has proved to be a challenge for micro-scale and meso-scale robots with large deflections. In this paper, we have developed a sensor by mounting an FBG fiber within a micromachined nitinol tube whose neutral axis is shifted to one side due to the machining.

Modular FBG Bending Sensor for Continuum Neurosurgical Robot.

We present a modular sensing system to measure the deflection of a minimally invasive neurosurgical intracranial robot: MINIR-II. The MINIR-II robot is a tendon-driven continuum robot comprised of multiple spring backbone segments, which has been developed in our prior work. Due to the flexibility of the spring backbone and unique tendon routing configuration, each segment of MINIR-II can bend up to a large curvature (≥100 m) in multiple directions.

Towards Patient-Specific 3D-Printed Robotic Systems for Surgical Interventions.

Surgical robots have been extensively researched for a wide range of surgical procedures due to the advantages of improved precision, sensing capabilities, motion scaling, and tremor reduction, to name a few. Though the underlying disease condition or pathology may be the same across patients, the intervention approach to treat the condition can vary significantly across patients. This is especially true for endovascular interventions, where each case brings forth its own challenges.