Cembranoids from the Red Sea soft coral Sarcophyton glaucum protect against indomethacin-induced gastric injury.

Soft corals and their secondary metabolites represent an exceptional source of potential drugs. In this regard, Sarcophyton glaucum-derived secondary metabolites were examined for their preventive activities against indomethacin-induced gastric ulcer. Extraction and chromatographic processing of a specimen of S.

Exploring the Mangrove Fruit: From the Phytochemicals to Functional Food Development and the Current Progress in the Middle East.

Nowadays, the logarithmic production of existing well-known food materials is unable to keep up with the demand caused by the exponential growth of the human population in terms of the equality of access to food materials. Famous local food materials with treasury properties such as mangrove fruits are an excellent source to be listed as emerging food candidates with ethnomedicinal properties. Thus, this study reviews the nutrition content of several edible mangrove fruits and the innovation to improve the fruit into a highly economic food product.

Monoterpene Indole Alkaloids from the Aerial Parts of Induce Cytotoxicity and Apoptosis in Human Adenocarcinoma Cells.

Chromatographic investigation of the aerial parts of the (Apocynaceae) resulted in the isolation of two new monoterpene indole alkaloids, 6--antirhine--methyl () and razyamide (), along with six known compounds, eburenine (), -rhazyaminine (), rhazizine (), 20--sitsirikine (), antirhine (), and 16--stemmadenine--oxide (). The chemical structures were established by various spectroscopic experiments. Compounds - exhibited cytotoxic effects against three cancer cells with IC values ranging between 5.

Antiproliferative Isoprenoid Derivatives from the Red Sea Alcyonacean .

From the soft coral seven isoprenoid derivatives were isolated, including a new xenicane diterpene, xeniolide O () and a new gorgostane derivative gorgst-3β,5α,6β,11α,20()-pentol-3-monoacetate (), along with three known sesquiterpenes (), a known diterpene (), and a known steroid (). The extensive analyses of the NMR, IR, and MS spectral data led to determination of their chemical structures. Compounds displayed a cytotoxic effect against breast adenocarcinoma (MCF-7), hepatocellular carcinoma (HepG2), and cervix adenocarcinoma (HeLa), with IC values ranging between 1.

Chemical Diversity and Bioactivities of Monoterpene Indole Alkaloids (MIAs) from Six Apocynaceae Genera.

By the end of the twentieth century, the interest in natural compounds as probable sources of drugs has declined and was replaced by other strategies such as molecular target-based drug discovery. However, in the recent times, natural compounds regained their position as extremely important source drug leads. Indole-containing compounds are under clinical use which includes vinblastine and vincristine (anticancer), atevirdine (anti-HIV), yohimbine (erectile dysfunction), reserpine (antihypertension), ajmalicine (vascular disorders), ajmaline (anti-arrhythmic), vincamine (vasodilator), etc.

Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga .

Three new rare C acetogenins (enyne derivatives ⁻) were isolated from the organic extract obtained from the red alga , collected from the Red Sea. The chemical structures of the isolated compounds were established by spectroscopical data analyses. Potent anti-inflammatory effect of the isolated metabolites was evidenced by inhibition of the release of inflammatory mediators (e.

Bio-active maneonenes and isomaneonene from the red alga Laurencia obtusa.

Three previously undescribed compounds, maneonenes and isomaneonene derivatives; in addition to five known compounds, two cuparene, one chamigrene, and two cis-maneonenes were isolated from the Red Sea red alga Laurencia obtusa. The chemical structures of all unknown metabolites were characterized employing spectroscopic methods and then were further confirmed by single crystal X-ray analysis. Jeddahenyne A has C-5-C-12 etheric linkage and C-13-C-14 carbon-carbon double bond; Jeddahenyne B has in addition to the aforementioned etheric linkage a C-13 carbonyl function and absence of halogenation, unusual features for the maneonenes while 12-debromo-12-methoxy isomaneonene A shows unrecorded methoxylation at C-12.

Isolaurenidificin and Bromlaurenidificin, Two New C-Acetogenins from the Red Alga Laurencia obtusa.

Chromatographic fractionation of the CH₂Cl₂/MeOH extract of the Red Sea red alga gave two new hexahydrofuro[3,2-]furan-based C-acetogenins, namely, isolaurenidificin () and bromlaurenidificin (). The chemical structures were elucidated based on extensive analyses of their spectral data. Compounds and showed no toxicity ( > 12 mM) using as test organism.