Publications by authors named "Nahed Elsisi"
Article Synopsis
- Defects in synaptic plasticity and function may contribute to symptoms in Angelman syndrome (AS) and autism spectrum disorder (ASD).
- Certain medications, like serotonin reuptake inhibitors and risperidone, can alleviate symptoms by affecting serotonin and dopamine levels.
- The study reveals a connection between the UBE3A gene and monoamine synthesis regulation, suggesting that variations in UBE3A expression may influence treatment responses in individuals with ASD or AS.
In case of injury or disease, microglia are recruited to the site of the pathology and become activated as evidenced by morphological changes and expression of pro-inflammatory cytokines. Evidence suggests that microglia proliferate by cell division to create gliosis at the site of pathological conditions such as the amyloid plaques in Alzheimer's disease and the substantia nigra of Parkinson's disease patients. The hyperactivation of microglia contributes to neurotoxicity.
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