[The intensity of processes of lipoperoxidation and antioxidant defense in patients with recurrent viral herpes infection].

The article discusses some parameters of free radical metabolism of lymphocytes of blood plasma in 65 patients with recurrent virus herpes infection in course of disease. It is established that in patients occurs increasing of both of level of malonic dialdehyde and functional activity of neutrophils in blood plasma. On the background of these alterations, compensatory increase of activity of such antioxidant enzymes as ceruloplasmin and catalase is noted.

[The antioxidant system in patients with influenza and influenza pneumonia].

The paper deals with the topical theme--the state of antioxidant protective components in influenza infection. The values of catalase in red blood cells and those of ceruloplasmin in plasma were studied as an indicator of antiperoxide defense. The patients were grouped according to the severity of their condition and associated complications.

[Immunomodulators in therapy for chronic virus hepatitis C].

The authors present the results of their investigations of clinical and immunological characteristics in chronic viral hepatitis C (CVHC). Cellular and humoral immunological parameters and cytokine profile, including the interferon status, were studied in relation to the activity of the process. Statistically significant clinical laboratory and immunological differences were found in patients (CVHC) receiving various treatment options.

[Nonspecific systemic resistance in patients with genital herpes].

The functional state of a thiol disulfide link of the antioxidant system was evaluated in 45 patients with recurrent herpesvirus infection in the recurrence and interrecurrence periods. Impaired free radical oxidation in these patients is one of the leading pathogenetic factors of biomembrane structural and functional changes. The study of the blood antioxidant system demonstrated that the patients with herpesvirus infections had lower levels of SH groups, decreased thiol/disulfide ratio, and higher content of SS groups, which shows the predominance of the oxidant system over the antioxidant ones.

[The parameters of the blood prooxidant and antioxidant systems in bacterial and viral pneumonias].

Aim: To determine the level of malondialdehyde (MDA) in plasma and nitro blue tetrasolium in leukocytes as parameters of the blood prooxidant system and the activity of ceruloplasmin (CP) in serum and erythrocyte catalase as the parameters of antioxidant activity in bacterial and viral pneumonias.

Subjects And Methods: The blood prooxidant and antioxidant systems were studied in 177 patients with bacterial and viral pneumonia over time.

Results: Heterodirectional changes were found in the parameters of the blood prooxidant and antioxidant systems in bacterial and viral pneumonias.

[Lipid peroxidation in pneumonia of bacterial and viral etiologies].

The blood prooxidant and antioxidant systems were studied in 165 patients with pneumonia of bacterial and viral etiologies over time. There was a regular and significant increase in the levels of malondialdehyde, spontaneous nitroblue tetrasolium test, and catalase in the red blood cells; in parallel to this, there was ceruloplasmin activity suppression that depended on etiology, stage, and severity. Much pronounced and long-term impairments of the activity and level of prooxidant and antioxidant indices were suggestive of a severer clinical course and the presence of complications and concomitant diseases of infectious and inflammatory nature.

[The cytokine profile in patients with bacterial quinsy].

The state of the proinflammatory cytokines tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL-6, and the anti-inflammatory cytokine IL-10 was studied in patients with bacterial quinsy over time. There were significant and heterodirectional changes in the plasma level of proinflammatory and anti-inflammatory cytokines with the normalization of their content in the period of late convalescence. The regular shifts of proinflammatory cytokines in patients with quinsy depended on the period and clinical forms of the disease, its severity, complications, comorbidity, and the plenitude of recovery.

[Time course of changes in lipid peroxidation parameters in patients with syphilis].

The prooxidative-antioxidative systems of plasma and blood corpuscles were evaluated in 151 patients with primary, secondary recent, secondary recurrent, and latent syphilis. The red blood cell levels of malonic dialdehyde, ceruloplasmin, and catalase were measured during the pathological process. The authors identified the following regularities: with active clinical manifestations of syphilis, there was a significant suppression of the blood antioxidative system and a substantial increase in the activity of the blood prooxidative system and blood corpuscles, with these parameters becoming normal after performed treatment.

[Profiles of lipid oxidation by a free radical mechanism in patients with bacterial sore throat].

Properties of prooxidative and antioxidative systems were investigated in 74 patients with bacterial sore throat. The results suggest a noticeable unidirectional change of the free radical status with marked amplification of prooxidative and attenuation of antioxidative activities depending on the clinical form of the disease, its severity, and the presence of concomitant pathologies.

[Prooxidative characteristics of plasma from the psoriatic patients based on malonic dialdehyde level].

The values of malonic dialdehyde (MDA) were studied in 152 patients with different forms of psoriasis during the pathological process. The level of MDA was found to depend on the severity and extent of the process and on the presence of complications. Higher and persistent changes in MDA levels were observed in patients with complicated and disseminated forms of the disease.

[Leukocytic functional and metabolic activity in patients with morphea guttata].

Cytochemical techniques were used to study the functional and metabolic activity of neutrophilic granulocytes in 36 patients with morphea guttata. The levels of major microbicidal components (cationic protein, glycogen, lipids, myeloperoxidase, and acid phosphatase) were measured during a pathological process. Extremely important regularities were revealed: with active clinical manifestations, there was a significant inhibition of the activity of myeloperoxidase, the level of cationic proteins, intracellular lipids and a considerable increase in the activity of acid phosphatase and the content of glycogen in the cells; normalization of leukocytic metabolic activity occurs at remission.

[Leukocytic intracellular components and proantioxidative systems in HIV-infected patients].

The present study was undertaken to examine the state of intracellular components and leukocytes and the role of the lipid peroxidation (LPO) system and antioxidative defense (AOD) in the pathogenesis of HIV infection. The parameters of the enzymatic link of the antioxidative system and LPO processes and leukocytic intracellular components in 108 patients with HIV infection are presented. In the HIV-infected patients, the state of intracellular components of leukocytes showed a heterodirectional pattern.

[Lipid peroxidation and antioxidant systems in patients with HIV infection].

Aim: To study lipid peroxidation (LPO) and anti-oxidant system (AOS) in patients with HIV infection.

Material And Methods: Enzymatic parameters of AOS and LPO were studied in 108 patients with HIV infection, 38 of them had HIV+HBV, HIV+HCV infection and 17 patients had associated tuberculosis.

Results: Severe alterations of LPO were found: a significant rise of LPO products, malonic dialdehyde and dienic conjugates.

[Implication of middle-mass molecule peptides of blood plasma in assessment of intoxication syndrome in patients with bacterial tonsillitis].

The level of middle-mass molecule peptides (MMMP) of blood plasma was investigated in 98 patients with tonsillitis. A significant increase in the level of MMMP with a maximal rise at the height of the disease with normalization in early and late convalescence was revealed. The changes in plasma MMMP in tonsillitis depended on the clinical form, stage and severity of the disease, complications, concomitant diseases, completeness of convalescence.

[The spread of hepatitis B and C viruses and the structure of HBsAg subtypes in Kabardino-Balkaria].

A seroepidemiological study of the spread of hepatitis B and C viruses (HBV and HCV) was conducted among some population groups in Kabardino-Balkaria. The structure of HBsAg subtypes was also studied in the residents of the republic. The presence of viral hepatitis B markers among the test groups of the healthy population corresponds to the parameters of moderate activity of an epidemic process.

[Morbidity in acute virus hepatitis B on the territory of Kabardin-Balkaria].

Morbidity in acute virus hepatitis B (AVHB) in Kabardin-Balkaria during the period of 1992 to 2003 was analyzed. The dynamics of changes in the age groups of AVHB patients, as well as in the structure of the transmission routes of the disease, was analyzed. The level of AVHB morbidity in the Kabardin-Balkar Republic was lower in recent years than the average level of such morbidity in the whole of Russia.

[T-lymphocyte subpopulations and tumor necrosis factor-alpha in patients with acute Flexner's dysentery].

In 41 patients aged 24-63 years with acute Flexner's dysentery T-lymphocyte subpopulations CD-3, CD-4, CD-8, IRI and the content of tumor necrosis factor alpha (TNF-alpha) in the blood serum were detected. The suppression of T-cell mediated immunity on account of the presence of CD-4 with decreased immunoregulatory index and an increased content of TNF-alpha were established. Changes in T-cell mediated immunity and TNF-alpha depended on the period and the severity of the diseases.

[Malondialdehyde and ceruloplasmin levels in plasma of patients with alimentary toxic infection].

The content of malonic dialdehyde and of ceruloplasmin in blood plasma was studied, as an indicator of the prooxidant-antioxidant system, in 84 patients, aged 21 to 63, with alimentary toxicoinfection. A higher level of malonic dialdehyde and a lower level of ceruloplasmin were detected, which depended on a disease stage and on a severity of the clinical course and pathologic progression.

[Role of the antioxidative defense system in the pathogenesis of acute viral hepatitides].

Aim: To study the activity of antioxidative defense enzymes and the total plasma antioxidative activity in patients with viral hepatitis B, C, and mixed hepatitis B + C.

Materials And Methods: 77 patients with viral hepatitis B, 90 with viral hepatitis C, and 25 with mixed hepatitis B + C were followed up. The activity of superoxide dismutase and catalase of leukocytes, and the total plasma antioxidative activity were determined at the peak of the disease, alleviation of clinical symptoms, and before discharge from hospital.

Effect of cytokines on the level of free radicals in the blood of patients with systemic and local staphylococcus infection.

An increased extracellular production of free radicals with bactericidal activity does not improve the efficacy of intracellular digestion of Staphylococci. The amount of intracellular oxygen reactive species generated by the neutrophils from patients with an infectious condition has been found considerably decreased as compared to healthy donors. On the other hand, the excess of secretion of free radicals into the extracellular space leads inevitably to the adaptive increase of antioxidant enzymes and, as a result, to an increase in the total antioxidant capacity of the blood plasma.

LPO and free-radical oxidation parameters in patients with acute viral hepatitis.

Serum MDA level and concentration of superoxide anion in leukocytes were measured in patients with acute hepatitis B and C at the peak of the disease, during regression, and during early convalescence. The concentration of active oxygen forms in leukocytes was maximum at the peak of the disease and decreased before discharge from the hospital.