Efficacy of and extracts against experimental infection.

Trichinellosis is a re-emerging zoonotic disease that has become a public health concern since its reported human outbreaks in many countries. The traditional therapy has many adverse effects in addition to the developing resistance. So, this necessitates finding effective natural alternatives.

and : a new take on therapy against experimental trichinellosis.

Trichinellosis is a zoonotic disease that endangers human health and can lead to death. Restricted absorption and poor results of conventional therapies demand new effective natural remedies to treat both enteral and parenteral trichinellosis. This study assessed the antiparasitic and anti-inflammatory effects of Citrus limon and Capsicum frutescens on murine trichinellosis and compared them with those of albendazole and prednisolone, which are conventionally used to treat trichinellosis.

Paeoniflorin in experimental BALB/c mansoniasis: A novel anti-angiogenic therapy.

Chronic hepatic schistosomiasis causes portal hypertension, fibrosis and lethal hepatosplenic complications. Previous studies focused mainly on schistosomicidal drugs and neglected the therapeutic approaches against the vascular complications after portal hypertension. Investigating a novel anti-angiogenic therapy is an urgent.

Evaluation of Artesunate and Praziquantel Combination Therapy in Murine .

Background: Despite the global efforts to control schistosomiasis, still prevalence in endemic regions unchanged. The present study was conducted to investigate the possible role of artesunate (AS) and praziquantel (PZQ) combination in enhancing cure in pre-patent and patent infection, and study the role of apoptosis in evaluation of the drugs efficacy.

Methods: Eighty laboratory-bred Swiss albino male mice were classified into four groups (20 mice each); control, PZQ treated (500 mg/kg), AS treated (400 mg/kg) and combined AS (400 mg/kg) + PZQ (500 mg/g) groups.

Paeoniflorin targets apoptosis and ameliorates fibrosis in murine schistosomiasis mansoni: A novel insight.

Schistosomiasis is a chronic helminthic disease causing hepatic fibrosis. Some studies demonstrated direct effect of targeting apoptosis on fibrosis regression. This study is a novel trial of Paeoniflorin (PAE) on S.

Anti-angiogenic and anti-lymphangiogenic role of praziquantel and artemether in experimental mansoniasis.

Angiogenesis is one of the pillars of neoplasia. Lymphangiogenesis in context of granulomas is not yet understood. This study aimed to evaluate the role of praziquantel (PZQ) and artemether (ART) as anti-angiogenic and anti-lymphangiogenic drugs in Schistosoma mansoni induced experimental hepatic model through immunohistochemical and serological studies, this can be used as a potential novel prophylactic approach in hepatic malignancy prevention and possible management.

IMMUNOPROTECTION OF SOLUBLE EGG ANTIGENS AND PRAZIQUANTEL IN CHALLENGED MURINE SCHISTOSOMIASIS MANSONI.

Control of schistosomiasis would be greatly improved by the development of a vaccine, which could be combined with chemotherapy. The current study evaluated the potential effect of soluble egg antigens (SEA) associated with or without PZQ in Schistosoma mansoni challenged mice through parasitological, histopathological and serological studies. Sixty Swiss albino fe- male mice divided into 5 groups (12 mice each); each group was subdivided into 2 groups (6 mice each) according initial and challenged infections.

SERO-PREVALENCE OF ANTI- TOXOPLASMA GONDII ANTIBODIES AMONG PATIENTS WITH NEUROPSYCHIATRIC DISORDERS: EPILEPSY AND DEPRESSION.

Toxoplasma gondii infection is concerned to have an association with epilepsy and depression either as a cause or a potential risk factor for their occurrence. Nevertheless, there has been long-standing interest in investigating this possible association, the evidence for such relationship is yet not conclusive. The current study correlated between T.

Molecular approach for detecting early prepatent Schistosoma mansoni infection in Biomphalaria alexandrina snail host.

The present study aimed to evaluate a polymerase chain reaction (PCR) assay used for detection of Schistosoma mansoni infection in Biomphalaria alexandrina snails in early prepatent period and to compare between it and the ordinary detection methods (shedding and crushing). Biomphalaria alexandrina snails are best known for their role as intermediate hosts of S. mansoni.

Geohelminths distribution as affected by soil properties, physicochemical factors and climate in Sharkyia governorate Egypt.

Soil-transmitted helminths are mainly a group of parasitic nematodes causing human infection through contact with parasite eggs or larvae; they survive in the warm and moist soil of the tropical and subtropical countries. This study was carried out in Sharkyia governorate from October, 2011 to October, 2013, to correlate between the prevalence and distribution of these parasites in the soil and the physicochemical factors affecting the examined samples of the soil. One hundred and twenty samples of different types of soil (clay, silt, sand) from different localities were collected and examined.

Studies on the role of tumor necrosis factor- alpha (TNF-α) in hepatocytes induced apoptosis in vaccinated, Schistosoma mansoni-challenged mice.

Tumour Necrosis Factor-alpha (TNF-α) plays a complex role in pathophysiological changes caused by schistosomiasis in the liver cells as induced apoptosis. So, The highlighted experimentally the role of TNF-α in hepatocytes apoptosis, using that as an assessment of the efficacy of antischistosomal vaccination by mixed crude antigens preparations [Cercarial antigen preparation (CAP) + soluble worm antigen preparation (SWAP) + soluble egg antigen(SEA)] by parasitological, histo-pathological and histochemical studies using Feulgen stain of hepatoytes DNA, a serological study also of serum TNF-α level by ELISA. Fifty two laboratory bred Albino male mice, were used in this study.